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Oral and respiratory bioacessibility of potentially toxic elements in urban soils and sediments

Grant number: 15/19332-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2016
Effective date (End): November 28, 2018
Field of knowledge:Agronomical Sciences - Agronomy - Soil Science
Principal Investigator:Luís Reynaldo Ferracciú Alleoni
Grantee:Alexys Giorgia Friol Boim
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
Associated scholarship(s):16/24483-9 - Oral and respiratory bioaccessibility of As, Cd, Cu, Pb and Zn from urban and mining soils (Part I), BE.EP.DR


Human beings can be exposed to potentially toxic elements (PTE) daily, especially those living in large urban center with heavy traffic and industrial activities, such as steel, metallurgy, and mining. Risk assessment methods can predict or indicate the exposure levels to contamination of an area. Beside the PTE pseudo-total contents in the soil extracted by acid solutions, the reactive, (bioavailable, the bioaccessible contents and the inert fraction of these elements are also determined to assess the degree of soil contamination. In this project, urban soil samples will be collected in Piracicaba, where the levels of contamination are low. Other samples will be collected in Apiaí, state of Sao Paulo, in the Centro Integrado de Ensino Multidisciplinar (CIEM/ Companhia de Pesquisa de Recursos Minerais - Geological Survey of Brazil); and in Santo Amaro, state of Bahia, where urban soils will be collected in residential areas, especially near the old mining and refining area, where many researchers have detected high levels of Pb, Cd and As. In these cities, there is a very large environmental liability and it is generating risks to the health of local population. In-vitro methods have been used to evaluate PTE bioaccesibility in humans in many countries. We will test procedures based on ingestion and inhalation of urban soils and sediments of Piracicaba. The Unified BARGE Method (UBM) and the Gamble's Solution will be used to determine the bioaccessible content in the gastrointestinal (GI) tract and in the lung fluid, respectively. However, the bioaccessible fraction does not estimate the concentration that is absorbed and transported to the bloodstream. Therefore, Caco-2 cell line will be employed as a model to simulate human intestinal epithelium. Mineralogical and geochemical characteristics of soils and sediments will be correlated to lung fluid and gastric juice.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BOIM, ALEXYS GIORGIA FRIOL; WRAGG, JOANNA; CANNIATTI-BRAZACA, SOLANGE GUIDOLIN; ALLEONI, LUIS REYNALDO FERRACCIU. Human intestinal Caco-2 cell line in vitro assay to evaluate the absorption of Cd, Cu, Mn and Zn from urban environmental matrices. ENVIRONMENTAL GEOCHEMISTRY AND HEALTH, v. 42, n. 2, p. 601-615, . (15/19332-9)
MAIONE, CAMILA; ARAUJO, ELOA MOURA; DOS SANTOS-ARAUJO, SABRINA NOVAES; FRIOL BOIM, ALEXYS GIORGIA; BARBOSA, ROMMEL MELGACO; FERRACCIU ALLEONI, LUIS REYNALDO. Determining the geographical origin of lettuce with data mining applied to micronutrients and soil properties. CIENTIA AGRICOL, v. 79, n. 1, p. 15-pg., . (12/03682-2, 15/19332-9, 15/25416-0)
FRIOL BOIM, ALEXYS GIORGIA; PATINHA, CARLA; WRAGG, JOANNA; CAVE, MARK; FERRACCIU ALLEONI, LUIS REYNALDO. Respiratory bioaccessibility and solid phase partitioning of potentially harmful elements in urban environmental matrices. Science of The Total Environment, v. 765, . (15/19332-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BOIM, Alexys Giorgia Friol. Human bioaccessibility and absorption by intestinal cells of potentially harmful elements from urban environmental matrices. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALA/BC) Piracicaba.

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