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"Action of a novel thiazolidinedione (GQ-11) in tissue repair process on experimental models of insulin resistance and vascular surgery.

Grant number: 16/00233-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2016
Effective date (End): May 31, 2019
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Dulcineia Saes Parra Abdalla
Grantee:Jacqueline Cavalcante Silva
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):16/19737-1 - Modulation of Inflammation and angiogenesis by a new thiazolidine compound (GQ-11) in visceral ischemia., BE.EP.DR   16/16850-1 - Modulation of tissue repair by a new thiazolidine compound (GQ-11) on experimental models of insulin resistance and visceral ischemia, BE.EP.DR


Thiazolidinediones (TZDs) comprise a class of hypoglycemic drugs which reduce insulin resistance in peripheral tissues. Evidences indicate that TZDs hypoglycemic effects is peroxisome proliferator-activated receptors (PPARs) mediated, on its gamma, alpha and/or beta/delta isoforms. Initially, three TZDs were approved to clinical use: troglitazone, rosiglitazone and pioglitazone. Recently, these drugs have been associated to important side effects, such as hepatotoxicity, cardiovascular risk and lipid profile alterations. Thus, the search for new thiazolidine compounds, which could share beneficial effects and minimize side effects were propelled. As a result, many new compounds have been developed and many others are on pre-clinical and clinical trials.Preliminary in vivo data showed that a new thiazolidine compound - GQ-11 - modulates cytokines with important role in inflammation processes turning it into a promising alternative on healing/ tissue repair therapy and treatment. In addition, it could be a special alternative at impaired metabolisms, such as in wound healing on diabetic patients and on vascular surgery, acting as a preventive agent of complications from an impaired inflammatory metabolism. In this sense, we propose deeply investigate and elucidate signaling pathways of inflammatory process and wound/tissue healing, allowing to understand GQ-11 action mechanisms and its benefits in two animal models: insulin resistance and visceral ischemia.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, JACQUELINE CAVALCANTE; BAVESTRELLO, MARGHERITA; GAZZOLA, VALERIO; SPINELLA, GIOVANNI; PANE, BIANCA; GRASSELLI, ELENA; DEMORI, ILARIA; CANESI, LAURA; EMIONITE, LAURA; CILLI, MICHELE; et al. Ischemia-reperfusion damage is attenuated by GQ-11, a peroxisome proliferator-activated receptor (PPAR)-a/? agonist, after aorta clamping in rats. Life Sciences, v. 297, p. 11-pg., . (12/51316-5, 16/16850-1, 16/00233-3)
SILVA, JACQUELINE C.; PITTA, MARINA G. R.; PITTA, IVAN R.; KOH, TIMOTHY J.; ABDALLA, DULCINEIA S. P.. New Peroxisome Proliferator-Activated Receptor Agonist (GQ-11) Improves Wound Healing in Diabetic Mice. ADVANCES IN WOUND CARE, v. 8, n. 9, p. 417-428, . (12/51316-5, 16/00233-3, 16/16850-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Jacqueline Cavalcante. Effects of a new thiazolidine compound (GQ-11) on tissue repair process in models of insulin resistance and ischemia-reperfusion. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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