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Plasticity tissue of the myotendinous junction soleus of aged Wistar rats ovariectomized submitted to swimming

Grant number: 15/21720-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2016
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal Investigator:Adriano Polican Ciena
Grantee:Luan Rissatto Sierra
Host Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil


The physiological process of aging results in several changes in the body systems where the resulting sarcopenia of muscle atrophy associated with menopause, several triggers morphological changes in muscle-tendon interaction area denominated myotendinous junction. Physical exercise may be result in benefits in the structure of myotendinous junction associated with a large increase in their contact area. The aim of this study is to analyze the tissue plasticity through the morphological analysis of myotendinous junction of the soleus in ovariectomized old Wistar rats submitted to swimming training. Will be used 40 rats aged with 1 year and 2 months old randomly divided into four groups (n = 10): Sedentary group; Trained group; Sedentary / Ovariectomized group and Trained / Ovariectomized group. The animals will be coming from the Central Animal Facility of UNESP - Botucatu-SP. The training protocol consist of 40 sessions, 1 hour daily, for a period of 8 weeks and loaded with 5% body weight of animals with weekly measurements for making adjustments. The obtained histological results will be analyzed by light microscopy, scanning electron microscopy and transmission electron microscopy, in order to demonstrate morphometric characteristics, three-dimensional aspects of structural and ultrastructural elements of the components at the cellular level.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SIERRA, LUAN RISSATTO; FAVARO, GABRIEL; CERRI, BRUNO RUBIN; ROCHA, LARA CAETANO; DE YOKOMIZO DE ALMEIDA, SONIA REGINA; WATANABE, II-SEI; CIENA, ADRIANO POLICAN. Myotendinous junction plasticity in aged ovariectomized rats submitted to aquatic training. MICROSCOPY RESEARCH AND TECHNIQUE, v. 81, n. 8, p. 816-822, . (15/21720-7)

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