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Mitochondrial Partitioning in Mammalian Cells.

Grant number: 15/25776-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2016
Effective date (End): April 30, 2018
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Alicia Juliana Kowaltowski
Grantee:Maria Fernanda Pereira de Araújo Demonte Forni
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID
Associated scholarship(s):16/22298-0 - Bioenergetic characterization of epidermal and dermal white adipose tissue progenitors in calorically-restricted mice: dissecting the role of mitochondrial metabolism in stem cell commitment and terminal differentiation, BE.EP.PD


Mitochondria are essential for energy metabolism in mammals. Although they are present in virtually all eukaryotic cells, very little is known about mitochondrial segregation during mitosis in mammals. Indeed, this process was long believed to be stochastic. Nonetheless, recent findings in yeast demonstrate that, when these cells are undergoing asymmetric cell division, mitochondrial sorting occurs, triggered by mechanisms that actively provide a subset of distinct mitochondria for each daughter cell. This process is implicated in aging and proliferation. Similar active addressing mechanisms have not been described in mammalian cells, and this is mainly due to the lack of an adequate model system to address this process. Here we propose that a good model to explore this question are skin stem cells, that, unlike many cells, can divide both symmetrically and asymmetrically. We will also address, using mouse embryonic fibroblasts, whether mitochondrial morphology is important for the segregation of these organelles and its impact on cell cycle progression. In this project, we will try to elucidate if mitochondria are partitioned differently in asymmetric and symmetric cell division in mammals, and also assess whether this event directly affects the fate acquired by skin stem cells during differentiation and its importance for cell cycle control.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TEOFILO SATURI DE CARVALHO, ANA ELISA; BASSANEZE, VINICIUS; FORNI, MARIA FERNANDA; KEUSSEYAN, ALINE ALFONSO; KOWALTOWSKI, ALICIA JULIANA; KRIEGER, JOSE EDUARDO. Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism. SCIENTIFIC REPORTS, v. 7, . (13/26440-7, 15/25776-7, 13/07937-8, 12/10109-7, 13/17368-0, 13/04871-6, 11/19678-1)
ASSIS-RIBAS, THAIS; FORNI, MARIA FERNANDA; BROCHADO WINNISCHOFER, SHEILA MARIA; SOGAYAR, MARI CLEIDE; TROMBETTA-LIMA, MARINA. Extracellular matrix dynamics during mesenchymal stem cells differentiation. Developmental Biology, v. 437, n. 2, p. 63-74, . (16/18277-7, 15/26328-8, 16/22298-0, 16/05311-2, 15/25776-7)
AMIGO, IGNACIO; DA CUNHA, FERNANDA M.; FORNI, MARIA FERNANDA; GARCIA-NETO, WILSON; KAKIMOTO, PAMELA A.; LUEVANO-MARTINEZ, LUIS A.; MACEDO, FELIPE; MENEZES-FILHO, SERGIO L.; PELOGGIA, JULIA; KOWALTOWSKI, ALICIA J.. Mitochondrial form, function and signalling in aging. Biochemical Journal, v. 473, n. 20, p. 3421-3449, . (15/15526-3, 13/04919-9, 10/51906-1, 14/17270-3, 13/07937-8, 15/25776-7)

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