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Cross-species expression profile of miRNAs related to fatty acids

Grant number: 16/03291-4
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): June 01, 2016
Effective date (End): September 30, 2016
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Luciana Correia de Almeida Regitano
Grantee:Priscila Silva Neubern de Oliveira
Supervisor abroad: James Reecy
Home Institution: Embrapa Pecuária Sudeste. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Research place: Iowa State University, United States  
Associated to the scholarship:14/22325-1 - Expression profile of microRNAs extreme animals for feed efficiency in Nelore breed, BP.PD


Fatty acids profile it is an economically important trait, which influences thesensorial and nutritional value of meat. Among the regulatory mechanisms, miRNAs have emerged as a new dimension in post-transcriptional regulation in mammals. Recent developments in molecular genetics,such as platforms for genotyping and genome sequencing in several experimentalconditions, currently allows the large-scale analysis of biological interactions andprocesses related to production traits. This study attempts to evaluate the extent towhich miRNA-mediated post-transcriptional regulation regulates gene expression intwo species, Bos indicus and Bos taurus, through comparison of miRNA data setsrelated to fatty acids. This study will provide additional information about miRNAs andtheir functional role in beef cattle. Ultimately, this will help to elucidate molecularmechanisms controlling traits of interest and then help to improve livestock production. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, PRISCILA S. N.; COUTINHO, LUIZ L.; CESAR, ALINE S. M.; DA SILVA DINIZ, WELLISON J.; DE SOUZA, MARCELA M.; ANDRADE, BRUNO G.; KOLTES, JAMES E.; MOURAO, GERSON B.; ZERLOTINI, ADHEMAR; REECY, JAMES M.; et al. Co-Expression Networks Reveal Potential Regulatory Roles of miRNAs in Fatty Acid Composition of Nelore Cattle. FRONTIERS IN GENETICS, v. 10, . (12/23638-8, 16/03291-4)
DE OLIVEIRA, PRISCILA S. N.; COUTINHO, LUIZ L.; TIZIOTO, POLYANA C.; CESAR, ALINE S. M.; DE OLIVEIRA, GABRIELLA B.; DINIZ, WELLISON J. DA S.; DE LIMA, ANDRESSA O.; REECY, JAMES M.; MOURAO, GERSON B.; ZERLOTINI, ADHEMAR; et al. An integrative transcriptome analysis indicates regulatory mRNA-miRNA networks for residual feed intake in Nelore cattle. SCIENTIFIC REPORTS, v. 8, . (12/23638-8, 16/03291-4)

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