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Temperature variation effects on AOX flies development

Grant number: 16/00013-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2016
Effective date (End): February 28, 2017
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal researcher:Marcos Túlio de Oliveira
Grantee:Geovana Siqueira Garcia
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:14/02253-6 - Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial alternative oxidase of Ciona intestinalis in Drosophila melanogaster, AP.JP


Temperature is one of the main factors influencing insect metabolism: low temperatures slow it down, consequently producing less ATP e increasing developmental time, whereas high temperatures accelerate metabolism, raising ATP production and reducing developmental time. Notably, alternative oxidases (AOX) of plants are involved directly in the temperature increase (thermogenesis) associated with floral development. Evaluating the effects of temperature in AOX flies will be of great importance for the understanding of this enzyme's role in mitochondrial function, and will answer the questions: is it possible that AOX expression alter the internal temperature of transgenic fruitflies, to the point of also altering metabolism and mitochondrial ATP production? (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAARI, SINA; GARCIA, GEOVANA S.; BREMER, KATHARINA; CHIODA, MARINA M.; ANDJELKOVIC, ANA; DEBES, PAUL V.; NIKINMAA, MIKKO; SZIBOR, MARTEN; DUFOUR, ERIC; RUSTIN, PIERRE; et al. Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1865, n. 4, SI, p. 854-866, . (14/02253-6, 16/00013-3, 15/02174-1)

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