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Evaluation of hepatic regeneration capacity and differential microRNAs expression in offspring from obese dams after a partial hepatectomy procedure

Grant number: 15/20991-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2016
Effective date (End): February 28, 2018
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal Investigator:Adriana Souza Torsoni
Grantee:Marina Figueiredo Fontana
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


In recent decades, obesity and metabolic syndrome have become diseases of high prevalence worldwide. Changes in lifestyle and eating habits, especially during critical periods of development, lead the progeny to important metabolic alterations through epigenetic mechanisms, such as modulation of miRNA expression, contributing to the maintenance of a "vicious cycle" of obesity and its comorbidities. Recent studies have shown that maternal obesity induces mitochondrial damage and activates inflammatory processes, changing the hepatic lipid metabolism in offspring. These alterations could increase the predisposition to developing diseases such as NAFLD, a disease characterized by TAG accumulation in hepatocytes which leads more than 20% of affected people to some type of liver resection. It is known that liver fat accumulation can be a detrimental factor in the regeneration process, although the mechanisms involved in this process are not well defined. Therefore, the aim of this work is to investigate whether offspring from obese dams have disturbances in the liver regeneration process following surgical resection procedure, and the relationship of its regeneration process with the expression of microRNAs involved in tissue repair modulation and cell cycle.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FONTANA, Marina Figueiredo. Evaluation of the expression of miR-370 and miR-122 and its participation in the regulation of the process of regeneration in offispring of obese mice submitted to partial hepatectomy surgery. 2018. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

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