Citrus therapy influence on healthy womens prostaglandin

Abstract

The PGF2± and PGE2, heavily produced during menstruation, are responsible for part of the endometrial contraction, causing severe uterine pain, known as dysmenorrhea. Depending on the intensity, cramps may be controlled by the use of anti-inflammatory drugs, blocking prostaglandin synthesis. However, this kind of therapeutic option produces side effects. In this sense, the use of phytotherapy products has been proposed as an alternative for the control of inflammatory symptoms. The Tahiti lemon (Citrus latifolia), has been shown to be effective in controlling the effects of menstruation in women who have deregulated cycles. However, these mechanisms are not entirely known, but the inhibition of the arachidonic acid cascade is one possibility. Thus, it is intended to study the effect of citrus therapy based on Tahiti lemon in the production of PGs in healthy women during menstruation. For this, fertile period women in the age group of 18-40 years will be invited and divided into three groups, depending on the stimulation that will be exhibited: Lemon Group (G1, n = 15), Meloxicam Group (G2, n = 15) and control group (G3, n = 15). The PGF2± production will be evaluated in the three groups, and the total blood and collected menstrual blood will be used for plasma dosage to compare uterine and systemic effects of citrus therapy.