Effects of aerobic exercise training in pulmonary changes induced by different products of air pollution

Abstract

Abstract: Physical activity is able to modulate the inflammatory response showing protective effects either in experimental models and clinical studies. The chronic exposure to particulate matter results in acute inflammatory reactions with cytokines and hormones release able to recruit acute-phase inflammatory cells and lead to tissue remodeling of the respiratory tract. Little is known about the ability of the physical training to attenuate the inflammatory process and less about its interference in the chronic lung inflammation leading to tissue remodeling. Objective: Evaluate the interference of the regular physical training on the chronic lung inflammation induced by the instillation of particulate matter in animal models. Methods: Male mice will be submitted to five weeks of aerobic training in exercise treadmills, together with weekly instillation of particulate matter of two different diameters (PM 2.5 and PM 10), compared to control mice with either only particulate matter instillation or exercise. There will be a comparison of both pulmonary and blood inflammatory cytokines and histologic alterations in both groups. Expected results: We expect to find if the regular physical activity is able to modulate the alterations due to chronic exposure to airborne particulate matter. We also expect to not only identify witch inflammatory cytokines involved in this inflammation, but also the interference in the lung remodeling event due to exposure to different size of particulate matter. (AU)