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The effect of cutaneous afferents in the mechanical somatosensory profile of masticatory myofascial pain.

Grant number: 15/09913-4
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): March 01, 2016
Effective date (End): September 17, 2018
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Leonardo Rigoldi Bonjardim
Grantee:Yuri Martins Costa
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated scholarship(s):18/00614-2 - Effects of experimental pain and local anesthesia on motor cortex excitability and its relationship with muscle sensitivity, BE.EP.PD

Abstract

Quantitative sensory testing (QST) is a recent option in the assessment of masticatory myofascial (MMF) pain. However, the role of superficial tissue sensitivity is not fully explored yet. The aim of this study is to evaluate the influence of cutaneous afferents in the mechanical somatosensory profile of subjects with MMF pain and healthy controls. This crossover placebo controlled clinical trial will comprise women with MMF pain (n = 20) and healthy controls (n = 20). The outcomes will be: a) reported facial pain intensity e b) 4 parameters of QST, which will be performed in the anterior temporalis and masseter region: 1) mechanical detection threshold (MDT), 2) mechanical pain threshold (MPT), 3) wind-up ratio (WUR) and 4) pressure pain threshold (PPT). The measurements will occur under the following conditions: a) baseline values, b) after the application of an anesthetic (lidocaine 4%) topical cream (experimental condition 1) and c) placebo cream (experimental condition 2). Multi-factors analysis of variance (ANOVA) with group (2 levels) and conditions (3 levels) and post hoc Tukey Honestly Statistical Difference test will be applied to the data considering a significance level of 5%.

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Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, YURI M.; DE SOUZA, PAULO ROBERTO J.; MARQUES, VANESSA A. S.; CONTI, PAULO CESAR R.; VIVAN, RODRIGO R.; DUARTE, MARCO ANTONIO H.; BONJARDIM, LEONARDO R.. Intraoral Somatosensory Alterations Impact Pulp Sensibility Testing in Patients with Symptomatic Irreversible Pulpitis. JOURNAL OF ENDODONTICS, v. 46, n. 6, p. 786-793, . (19/06035-7, 15/09913-4)
COSTA, Y. M.; KARLSSON, P.; BONJARDIM, L. R.; CONTI, P. C. R.; TANKISI, H.; JENSEN, T. S.; NYENGAARD, J. R.; SVENSSON, P.; BAAD-HANSEN, L.. Trigeminal nociceptive function and oral somatosensory functional and structural assessment in patients with diabetic peripheral neuropathy. SCIENTIFIC REPORTS, v. 9, . (15/09913-4)
COSTA, Y. M.; MORITA-NETO, O.; DE ARAUJO-JUNIOR, E. N. S.; SAMPAIO, F. A.; CONTI, P. C. R.; BONJARDIM, L. R.. Test-retest reliability of quantitative sensory testing for mechanical somatosensory and pain modulation assessment of masticatory structures. Journal of Oral Rehabilitation, v. 44, n. 3, p. 197-204, . (15/09913-4, 13/20236-9)
COSTA, YURI MARTINS; ALVES DA COSTA, DAYSE REGINA; DE LIMA FERREIRA, ANA PAULA; PORPORATTI, ANDRE LUIS; SVENSSON, PETER; RODRIGUES CONTI, PAULO CESAR; BONJARDIM, LEONARDO RIGOLDI. Headache Exacerbates Pain Characteristics in Temporomandibular Disorders. JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, v. 31, n. 4, p. 339-345, . (11/04441-6, 15/09913-4)
COSTA, YURI MARTINS; FERREIRA, DYNA MARA A. O.; CONTI, PAULO CESAR R.; BAAD-HANSEN, LENE; SVENSSON, PETER; BONJARDIM, LEONARDO R.. Topical anaesthesia degree is reduced in temporomandibular disorders patients: A novel approach to assess underlying mechanisms of the somatosensory alterations. Journal of Oral Rehabilitation, v. 47, n. 2, . (15/09913-4)
COSTA, YURI M.; EXPOSTO, FERNANDO G.; KOTHARI, MOHIT; CASTRILLON, EDUARDO E.; CONTI, PAULO CESAR R.; BONJARDIM, LEONARDO R.; SVENSSON, PETER. Masseter corticomotor excitability is decreased after intramuscular administration of nerve growth factor. EUROPEAN JOURNAL OF PAIN, v. 23, n. 9, . (15/09913-4, 18/00614-2)
ARAUJO OLIVEIRA FERREIRA, DYNA MARA; COSTA, YURI MARTINS; DE QUEVEDO, HENRIQUE MULLER; BONJARDIM, LEONARDO RIGOLDI; RODRIGUES CONTI, PAULO CESAR. Experimental Psychological Stress on Quantitative Sensory Testing Response in Patients with Temporomandibular Disorders. JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, v. 32, n. 4, p. 428-435, . (15/09913-4)
SAMPAIO, FERNANDA A.; SAMPAIO, CLAUDINE R. A.; CUNHA, CAROLINA O.; COSTA, YURI M.; ALENCAR, PHILLIPE N. B.; BONJARDIM, LEONARDO R.; GARIB, DANIELA; GARLET, GUSTAVO P.; ELIAV, ELI; CONTI, PAULO C. R.. The effect of orthodontic separator and short-term fixed orthodontic appliance on inflammatory mediators and somatosensory function. Journal of Oral Rehabilitation, v. 46, n. 3, p. 257-267, . (14/18741-0, 15/09913-4)
COSTA, YURI M.; BONJARDIM, LEONARDO R.; CONTI, PAULO CESAR R.; SVENSSON, PETER. Psychophysical evaluation of somatosensory function in oro-facial pain: achievements and challenges. Journal of Oral Rehabilitation, v. 48, n. 9, . (15/09913-4)
COSTA, YURI MARTINS; BAAD-HANSEN, LENE; BONJARDIM, LEONARDO RIGOLDI; RODRIGUES CONTI, PAULO CESAR; SVENSSON, PETER. Reliability of the nociceptive blink reflex evoked by electrical stimulation of the trigeminal nerve in humans. CLINICAL ORAL INVESTIGATIONS, v. 21, n. 8, p. 2453-2463, . (15/09913-4)
COSTA, Y. M.; ARIJI, Y.; FERREIRA, D. M. A. O.; BONJARDIM, L. R.; CONTI, P. C. R.; ARIJI, E.; SVENSSON, P.. Muscle hardness and masticatory myofascial pain: Assessment and clinical relevance. Journal of Oral Rehabilitation, v. 45, n. 8, p. 640-646, . (15/09913-4)
ANA PAULA DE LIMA FERREIRA; DAYSE REGINA ALVES DA COSTA; ANA IZABELA SOBRAL DE OLIVEIRA; ELYSON ADAM NUNES CARVALHO; PAULO CÉSAR RODRIGUES CONTI; YURI MARTINS COSTA; LEONARDO RIGOLDI BONJARDIM. Short-term transcutaneous electrical nerve stimulation reduces pain and improves the masticatory muscle activity in temporomandibular disorder patients: a randomized controlled trial. Journal of Applied Oral Science, v. 25, n. 2, p. 112-120, . (15/09913-4)
COSTA, Y. M.; DE ARAUJO-JUNIOR, E. N. S.; FIEDLER, L. S.; DE SOUZA, P. R. J.; SILVA, L. L. C. P.; FERREIRA, D. M. A. O.; CONTI, P. C. R.; BONJARDIM, L. R.. Reproducibility of quantitative sensory testing applied to musculoskeletal orofacial region: Site and sex differences. EUROPEAN JOURNAL OF PAIN, v. 23, n. 1, p. 81-90, . (15/09913-4)
COSTA, YURI MARTINS; CASTRILLON, EDUARDO E.; BONJARDIM, LEONARDO RIGOLDI; CONTI, PAULO CESAR RODRIGUES; BAAD-HANSEN, LENE; SVENSSON, PETER. Effects of Experimental Pain and Lidocaine on Mechanical Somatosensory Profile and Face Perception. JOURNAL OF ORAL & FACIAL PAIN AND HEADACHE, v. 31, n. 2, p. 115-123, . (15/09913-4)
COSTA, YURI MARTINS; RODRIGUES CONTI, PAULO CESAR; CARDOSO DE FARIA, FLAVIO AUGUSTO; BONJARDIM, LEONARDO RIGOLDI. Temporomandibular disorders and painful comorbidities: clinical association and underlying mechanisms. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 123, n. 3, p. 288-297, . (15/09913-4)
COSTA, YURI M.; EXPOSTO, FERNANDO G.; CASTRILLON, EDUARDO E.; CONTI, PAULO CESAR R.; BONJARDIM, LEONARDO R.; SVENSSON, PETER. Local anaesthesia decreases nerve growth factor induced masseter hyperalgesia. SCIENTIFIC REPORTS, v. 10, n. 1, p. 11-pg., . (15/09913-4, 18/00614-2)

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