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Neuroimunoendócrinos aspects in patients with Oral Lichen Planus

Grant number: 15/22183-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2016
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Maria José Alves da Rocha
Grantee:Karla Karine Duarte Maia
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Oral lichen planus (OLP), a chronic inflammatory disease that affects the skin and mucosa, affects mainly women, with prevalence of 0,1 and 4% in the population. This project proposes to determine the levels of cortisol and NO present in the saliva of patients with OLP in order to study neuroimunoendocrine aspects of this disease and if it is possible to establish biomarkers that can act in the diagnosis. The sample will be composed of 30 individuals aged 25 to 60 years, 15 with proven diagnosis of OLP and 15 healthy subjects (control group). Data related to age, sex, race, clinical form, site, and association with psicological factors and drugs use will be evaluated. This study is part of the Project: Clinical, histopathological and immunopathological profile of patients diagnosed with oral lichen planus, and was previously approved by the Ethics Review Board - FORP/USP (CAAE 33703114.8.0000.5419). (AU)

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