Advanced search
Start date
Betweenand

Effect of a TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months

Grant number: 15/14149-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2016
Effective date (End): August 31, 2019
Field of knowledge:Health Sciences - Dentistry - Social and Preventive Dentistry
Principal Investigator:Ana Carolina Magalhães
Grantee:Beatriz Martines de Souza
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

The aim of the present study is to evaluate the effect of 4% TiF4 varnish compared to a commercial 5% NaF varnish on the prevention of dental caries and on the remineralization of non-cavitated enamel carious lesions (white spot lesions) in permanent teeth of children living in fluoridated area. This randomized, longitudinal and blind clinical trial will involve 60 children, 7-12 years old, living in Bauru-SP/Brazil. Two examiners will evaluate the public school children. The children will be selected according to their caries activity (presence of active white spot lesion) and randomly divided into the following treatment groups: G1- 4% TiF4 varnish (2.45 % F-, pH 1, FGM- DentsCare); G2- 5% NaF varnish (2.26% F, pH 5, Duraphat®, Colgate) and G3- control (placebo varnish without fluoride, pH 5, FGM- DentsCare). The treatment will consist of the varnishes applications on all surfaces of permanent teeth, once a week for a period of 4 initial weeks (4 applications/1 month) and one application after 6 and 12 months. Clinical examination will be carried out by two examiners previously calibrated, after inter and intra-examiner agreement (kappa> 0.8), at baseline (before the first application), after 1, 6, 12 and 18 months of the beginning of study. The DMFT index will be applied to analysis the prevention of caries lesions by the application of the treatments. For the analysis of the progression or reversion of white spot lesions will be considered: the criterion of caries activity diagnosis (active versus inactive, Nyvad index) and quantitative fluorescence (”F, ”Q and lesion area) measured using quantitative light-induced fluorescence equipment (QLF). The data will be submitted to appropriate statistical test (parametric or non-parametric), after checking the data normality and homogeneity (p<0.05).

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, BEATRIZ MARTINES; SILVA, MAYARA DE SOUZA; BRAGA, ALINE SILVA; SOARES DOS SANTOS, DAIANA MORELI; CARVALHO, THAMYRIS DE SOUZA; DOS SANTOS, NATALIA MELLO; RIOS, DANIELA; RABELO BUZALAF, MARILIA AFONSO; MAGALHAES, ANA CAROLINA. Acceptability and effect of TiF4 on dental caries: a randomized controlled clinical trial. Brazilian Oral Research, v. 35, . (15/14149-1, 19/07241-0)
SOUZA, BEATRIZ MARTINES; SOARES SANTOS, DAIANA MORELI; BRAGA, ALINE SILVA; DOS SANTOS, NATALIA MELLO; RIOS, DANIELA; RABELO BUZALAF, MARILIA AFONSO; MAGALHAES, ANA CAROLINA. Effect of a Titanium Tetrafluoride Varnish in the Prevention and Treatment of Carious Lesions in the Permanent Teeth of Children Living in a Fluoridated Region: Protocol for a Randomized Controlled Trial. JMIR RESEARCH PROTOCOLS, v. 7, n. 1, . (15/14149-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Beatriz Martines de. Effect of TiF4 varnish in the prevention and remineralization of caries lesions in permanent teeth of children living in a fluoridated region: randomized clinical trial of 18 months. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

Please report errors in scientific publications list using this form.