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Determination of the main representatives of polybrominated diphenyl ethers class (PBDEs) in fish, eggs and milk employing microextraction packed sorbent (MEPS) and gas chromatography coupled with mass spectrometry (GC-MS)

Grant number: 15/19665-8
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2016
Effective date (End): March 01, 2019
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal researcher:Fernando Barbosa Júnior
Grantee:Marília Cristina Oliveira Souza
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):16/23372-9 - Exposure of Brazilian pregnant women to perfluorinated compounds in blood: levels and correlations with potential health implications., BE.EP.DR


Industrial development and the intense human activity expose the population to a new category of contaminants, emerging contaminants, among which stand out the flame retardants, such as polybrominated diphenyl ethers (PBDEs). PBDEs are used to prevent fires in electronics, textile and automotive industries and in construction materials. These contaminants are stable in the environment and can accumulate in the aquatic food chain introducing deleterious effects on human health such as hepatotoxicity, neurotoxicity, immune and endocrine damages. The main routes of exposure include inhalation, dust ingestion and through diet (fish, meat and eggs, dairy products and vegetables). Scientific literature has shown several sample preparation methods for the determination of PBDEs in food. However, these procedures are tedious and require high consumption of solvents and samples. Based on the above considerations, the present study aims to develop and validate a method of analysis of the main congener of PBDEs in fish, chicken eggs and cow's milk samples by using microextraction packed sorbent (MEPS) and gas chromatography-mass spectrometry (GC-MS). After the method development, it will be applied to evaluate the levels of PBDEs in several Brazilian food samples. In this sense, the results of this study will provide preliminary and unpublished data regarding PBDE levels in food consumed in Brazil.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; OLIVEIRA SOUZA, JULIANA MARIA; JACINTO SOUZA, JOAO CARLOS; BARBOSA, FERNANDO. Levels of polybrominated diphenyl ethers in Brazilian food of animal origin and estimation of human dietary exposure. Food and Chemical Toxicology, v. 150, APR 2021. Web of Science Citations: 0.
OLIVEIRA SOUZA, MARILIA CRISTINA; SARAIVA, MARIA CONCEICAO PEREIRA; HONDA, MASATO; BARBIERI, MARCO ANTONIO; BETTIOL, HELOISA; BARBOSA, FERNANDO; KANNAN, KURUNTHACHALAM. Exposure to per- and polyfluorinated alkyl substances in pregnant Brazilian women and its association with fetal growth. Environmental Research, v. 187, AUG 2020. Web of Science Citations: 0.
OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; OLIVEIRA SOUZA, JULIANA MARIA; BERRETTA, ANDRESA APARECIDA; BARBOSA, JR., FERNANDO. A Fast and Simple Procedure for Polybrominated Diphenyl Ether Determination in Egg Samples by Using Microextraction by Packed Sorbent and Gas Chromatography-Mass Spectrometry. FOOD ANALYTICAL METHODS, v. 12, n. 7, p. 1528-1535, JUL 2019. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SOUZA, Marília Cristina Oliveira. Determination of polybrominated diphenyl ethers (PBDEs) in foods commercialized in Brazil employing microextraction by packed sorbent (MEPS) and daily intake estimated. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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