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Retrospective study: evaluation of the clinical manifestations in pregnant women and newborns with toxoplasmosis treated at a clinic SUS 2009 to 2013

Grant number: 15/20350-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2017
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Cinara de Cássia Brandão
Grantee:Mariana Reis Nogueira
Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil


Toxoplasmosis is an infectious disease caused by the parasite Toxoplasma gondii. Despite being asymptomatic when affects immunocompetent individuals, it is high risk to infected pregnant women and their babies by the adverse effects it can generate. The aim of this project is to evaluate pregnant women with suspected pregnancy / congenital toxoplasmosis. Specific objectives include: 1. assess the clinical condition of pregnant women infected with T. gondii during prenatal care; 2. identify the recommended treatment during pregnancy; 3. identify and assess the conditions presented by the newborns; 4. identify and evaluate the conditions of children and the answers to these treatment continued for at least the first 18 months after birth. Will be evaluated the data of pregnant women such as gestational age, appropriate treatment, clinical diagnosis, laboratory diagnosis, among others that may be relevant in the clinical evaluation. Especially of pregnant women who underwent amniocentesis for the molecular diagnosis of toxoplasmosis by PCR (Polymerase Chain Reaction), featuring fetal infection by T. gondii. Serological data will be analyzed (used methods, antibody classes identified, etc.); of their newborns and children will be assessed the neurological development, auditory, visual, appropriate treatment and other medical conditions potentially related to toxoplasmosis and correlated with maternal conditions and their potential relationships of cause and effect. The data collected will be compared using the Fisher exact test and the chi-square or (where appropriate) and t test (for continuous variables). They will also calculate the values of odds ratios and confidence interval of 95%. The alpha value adopted will be 5%. It is expected that the results may contribute to elucidate the effects of gestational and congenital infections by T. gondii in affected children.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONIFACIO, LILLIAN GONZALEZ; MELO, MIRELE; AYO, CHRISTIANE MARIA; PARABOLI ASSONI, LETICIA CAROLINA; OLIMPIO, LARISSA MARTINS; NOGUEIRA, MARIANA REIS; FRANCO SPEGIORIN, LIGIA COSENTINO JUNQUEIRA; ULISSES BARBOSA, DEUSENIA MACHADO; DE MATTOS, LUIZ CARLOS; PEREIRA-CHIOCCOLA, VERA LUCIA; et al. TNF alpha rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis. MOLECULAR BIOLOGY REPORTS, v. 49, n. 6, p. 10-pg., . (15/20350-1, 18/04709-8, 19/08385-5)

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