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Assessment of viral and epidemiological fitness differences between two lineages of Dengue serotype 1 co-circulating during 2010-2012 in São José do Rio Preto, SP

Grant number: 15/22750-7
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2016
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Tauyne Menegaldo Pinheiro
Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Associated research grant:13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018, AP.TEM


Dengue is an acute febrile disease transmitted by Aedes mosquitoes (Ae. aegypti and Ae. albopictus), which has become a major public health problem worldwide. Approximately 40% of world's population live in endemic areas and the eradication is directly related to the control of its vector. Currently, Dengue virus is considered one of the major arbovirus because of its spread to several tropical and subtropical regions where the vector fits best. It's belongs to the Flavivirus genus and has four serotypes (1-4) subdivided into genotypes and lineages with different biological characteristics and complex dynamics of circulation. Several factors influence the replacement of a genotype and/or lineage on population. This project will assess viral and epidemiological fitness differences in vitro, in vivo and in silico between isolates from two lineages of DENV-1 co-circulating during 2010-2012 in São José do Rio Preto, chosen based on previous phylogenetic analysis. The study has being developed at Laboratório de Pesquisa em Virologia, FAMERP, and will perform analyzes considering the virus, vector and host interaction to correlate molecular, biological and epidemiological characteristics between the lineages to provide data on the fitness of DENV. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINHEIRO, TAUYNE MENEGALDO; DE OLIVEIRA MOTA, MANLIO TASSO; ARANHA WATANABE, ARIPUANA SAKURADA; BISELLI-PERICO, JOICE MATOS; DRUMOND, BETANIA PAIVA; RIBEIRO, MILENE ROCHA; VEDOVELLO, DANILA; ARAUJO, JR., JOAO PESSOA; PAOLUCCI PIMENTA, PAULO FILEMON; CHAVES, BARBARA APARECIDA; et al. Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil. PLoS Neglected Tropical Diseases, v. 12, n. 5, . (15/22750-7, 13/21719-3, 12/11733-6)

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