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Effect of perbiotic, probiotic and simbiotic on periodontal tissues of passive smoking rats

Grant number: 15/22837-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2016
Effective date (End): December 31, 2016
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Luciana Prado Maia
Grantee:Yara Loyanne de Almeida Silva Levi
Host Institution: Faculdade de Ciências da Saúde (FCSA). Universidade do Oeste Paulista (UNOESTE). Presidente Prudente , SP, Brazil


Smoking is one of the main risk factors for periodontal disease, increasing its prevalence and severity. Functional food appeared to modulate the gastrointestinal tract balance and activating the immune system, and the literature has shown promising results in the use of probiotics to control periodontitis. Aim: To evaluate the effects of prebiotics (MOS), probiotics (PRO) and synbiotics (S) on the onset and progression of periodontal disease caused by passive exposure to cigarette smoke in rats. Methods: It was used 96 male rats, randomly divided into two groups: with exposure to smoking for one hour daily, divided into two half-hour periods (T) and without exposure to smoking. These two groups were subdivided according to the dietary protocol into: Control Group (CG) = basal diet; CGT; GMOS; GMOST; GPRO; GPROT; GS; GST. 90 days after exposure to smoking, the right jaws will be collected and processed for histological and histomorphometric analysis. Results analysis method: The amount of inflammation and bone loss on first molars will be measured. The data will be submitted to normality tests and then the appropriate statistical tests will be applied. Expected results: It is expected to show that the use of the association of probiotics, prebiotics and symbiotic could be considered an important ally in the treatment of periodontal disease in passive smokers.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
YARA LOYANNE DE ALMEIDA SILVA LEVI; RAQUEL NARCISO PICCHI; EVELYN KELLYN TRINDADE SILVA; HERMANN BREMER NETO; ROSANA LEAL DO PRADO; ADRIELI DE PAULA NEVES; MICHEL REIS MESSORA; LUCIANA PRADO MAIA. Probiotic Administration Increases Mandibular Bone Mineral Density on Rats Exposed to Cigarette Smoke Inhalation. Brazilian Dental Journal, v. 30, n. 6, p. 634-640, . (15/22837-5)

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