Smoking is one of the main risk factors for periodontal disease, increasing its prevalence and severity. Functional food appeared to modulate the gastrointestinal tract balance and activating the immune system, and the literature has shown promising results in the use of probiotics to control periodontitis. Aim: To evaluate the effects of prebiotics (MOS), probiotics (PRO) and synbiotics (S) on the onset and progression of periodontal disease caused by passive exposure to cigarette smoke in rats. Methods: It was used 96 male rats, randomly divided into two groups: with exposure to smoking for one hour daily, divided into two half-hour periods (T) and without exposure to smoking. These two groups were subdivided according to the dietary protocol into: Control Group (CG) = basal diet; CGT; GMOS; GMOST; GPRO; GPROT; GS; GST. 90 days after exposure to smoking, the right jaws will be collected and processed for histological and histomorphometric analysis. Results analysis method: The amount of inflammation and bone loss on first molars will be measured. The data will be submitted to normality tests and then the appropriate statistical tests will be applied. Expected results: It is expected to show that the use of the association of probiotics, prebiotics and symbiotic could be considered an important ally in the treatment of periodontal disease in passive smokers.
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