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Study of lipid based nanoparticles as carriers for anticancer ruthenium metallodrugs

Grant number: 15/24252-4
Support Opportunities:Scholarships abroad - Research Internship - Doctorate (Direct)
Effective date (Start): May 01, 2016
Effective date (End): April 30, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Denise de Oliveira Silva
Grantee:Samara Rodrigues Alves
Supervisor: Xiao Yu Wu
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Toronto (U of T), Canada  
Associated to the scholarship:14/23481-7 - Study of lipid-based nanoparticles as carriers for anticancer ruthenium metallodrugs, BP.DD


Ruthenium compounds have received great attention in the field of metallodrugs because of their potential as anticancer agents. Complexes containing Ru2(II,III) dimetal cores coordinated to non-steroidal anti-inflammatory drugs (NSAIDs) developed in our research group have shown promising results in studies in vitro and in vivo in glioma models, such as the glioblastoma multiforme, a highly malignant brain cancer. The main objective of this proposal for Sandwich stage is to investigate the feasibility of developing hybrid nanoparticle lipid systems with Ru2(II,III)-NSAID complexes aiming to promote loading and sustained release of the metallodrugs in the brain. Lipid nanoparticles developed by Dr. Wu's group, such as lipid-terpolymer nanoparticles, were found to be capable of crossing the blood brain barrier, thus showing potential for treatment of gliomas, and allowing, among other things, to increase the intracellular and intratumor bioavailability and to decrease the systemic toxicity of antitumor drugs. In this context, the main goals of this research plan are: 1) to develop methodology for preparation of lipid nanoparticles, as Solid Lipid Nanoparticles (SLNs) and lipid-terpolymer nanoparticles, containing the metallodrugs; 2) to characterize the hybrid nanoparticles by diverse techniques; 3) to investigate the feasibility of releasing the metallodrugs from the hybrid materials; 4) to perform studies in vitro in order to verify the potential application of the new systems in anticancer treatments. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALVES, SAMARA RODRIGUES; COLQUHOUN, ALISON; WU, XIAO YU; SILVA, DENISE DE OLIVEIRA. Synthesis of terpolymer-lipid encapsulated diruthenium(II,III)-anti-inflammatory metallodrug nanoparticles to enhance activity against glioblastoma cancer cells. Journal of Inorganic Biochemistry, v. 205, . (14/23481-7, 15/24252-4, 14/23047-5)
ALVES RICO, SAMARA R.; ABBASI, AZHAR Z.; RIBEIRO, GEISE; AHMED, TAKSIM; WU, XIAO YU; SILVA, DENISE DE OLIVEIRA. Diruthenium(II,III) metallodrugs of ibuprofen and naproxen encapsulated in intravenously injectable polymer-lipid nanoparticles exhibit enhanced activity against breast and prostate cancer cells. NANOSCALE, v. 9, n. 30, p. 10701-10714, . (14/23047-5, 14/23481-7, 15/24252-4, 11/06592-1)

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