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A preliminary investigation of the anti-Helicobacter pylori by some Copaifera spp. species

Grant number: 15/19714-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): November 30, 2016
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Carlos Henrique Gomes Martins
Grantee:Lucas Kozoski de Lima
Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Associated research grant:11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species, AP.TEM


Gastric infections are still of concern to areas such as microbiology, gastroenterology and particularly oncology, since often the presence of Helicobacter pylori bacteria is directly related to severe clinical conditions such as infections, which may progress to the development of stomach cancer. The use of natural plants for medicinal purposes is an ancient custom and today is widely used in the pharmaceutical industry and in folk medicine. Among the medicinal plants with great pharmacological potential we can highlight the copaiba, trees capable of producing resin oils with various pharmacological properties and widely used in Brazilian folk medicine. The study of this herbal plant species relies primarily as anti-inflammatory, antimicrobial, immunomodulatory, anti-oxidant, healing, among others. This project aims to evaluate the antibacterial activity of the oil-resin copal, against H. pylori strain from in vitro assays. To evaluate the antibacterial activity will use the dilution method in broth with a view to determining the minimum inhibitory concentration (MIC), Bactericidal Concentrations Minimum (CBM), and will still be determined from promising results of the CIM, kinetics bacterial (Time Kill Assay).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORAES, THAIS DA SILVA; LIMA, LUCAS KOZOSKI; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; DOS SANTOS, RAQUEL ALVES; DA SILVA, JONAS JOAQUIM MANGABEIRA; RIBEIRO, GUSTAVO LIMA; BASTOS, JAIRO KENUPP; MARTINS, CARLOS HENRIQUE GOMES. In vitro Antibacterial Potential of the Oleoresin, Leaf Crude Hydroalcoholic Extracts and Isolated Compounds of the Copaifera spp. Against Helicobacter pylori. JOURNAL OF BIOLOGICALLY ACTIVE PRODUCTS FROM NATURE, v. 11, n. 2, p. 7-pg., . (11/13630-7, 15/19714-9, 12/25237-0)

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