Scholarship 15/22513-5 - Transaminases, Biocatálise - BV FAPESP
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Biocatalytic processes involving transaminases and imine reductases for the synthesis of ant venom alkaloids.

Grant number: 15/22513-5
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Start date until: August 01, 2016
End date until: July 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Anita Jocelyne Marsaioli
Grantee:Bruna Zucoloto da Costa
Supervisor: Nicholas John Turner
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Institution abroad: University of Manchester, England  
Associated to the scholarship:14/22967-3 - Piperidine and Pyrrolidine Alkaloids Synthesis in Multi-enzymatic systems, BP.PD

Abstract

Fire ant venom are comprised by piperidine, pyrrolidine, piperideine, pyrroline, indolizidine and pyrrolizidine alkaloids. These compounds are widely reported in the literature, mainly due to their biological activities such as insecticidal, fungicidal, bactericidal and hemolytic. However, the importance of the absolute configuration to these activities has been underexploited due to the scarcity of pure enantiomers either in nature or in synthetic samples. In this context, this project proposes the use of multi-enzymatic cascade processes involving transaminases and imine reductases for the production of enantiomeric pure piperidine and pyrrolidine alkaloids from their respective diketones. This project will help to stablish future biological activity studies regarding these alkaloids and their derivatives.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA, BRUNA Z.; GALMAN, JAMES L.; SLABU, IUSTINA; FRANCE, SCOTT P.; MARSAIOLI, ANITA J.; TURNER, NICHOLAS J.. Synthesis of 2,5-Disubstituted Pyrrolidine Alkaloids via A One-Pot Cascade Using Transaminase and Reductive Aminase Biocatalysts. CHEMCATCHEM, v. 10, n. 20, p. 4733-4738, . (15/22513-5, 14/22967-3, 14/50249-8)

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