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Influence of green tea on cardiac energy metabolism of mice exposed to doxorubicin

Grant number: 15/14832-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2015
Effective date (End): October 31, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Paula Schmidt Azevedo Gaiolla
Grantee:Letícia Correa da Costa Molina
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Doxorubicin or Adriamycin is an antibiotic in the class of Antraciclinas used as a potent chemotherapy in the treatment of several types of cancer. However, it has undesirable effects, such as cardiotoxicity. Each dose of doxorubicin administered can start heart injury worsening cumulatively. Different mechanisms involved in cardiotoxicity have been proposed, such as changes in energy metabolism. Therefore, studies are needed of compounds that can mitigate the injury. After water, green tea (CamelliaSinensis) is the most consumed beverage in the world. The antioxidant, anti-inflammatory and antiapoptóticas properties of green tea are potentially beneficial in contain the remodeling process. The objective of this work is to evaluate if the green tea extract attenuates cardiac remodeling induced by doxorubicin, by assessing the energy metabolism and its impact on shape, size, geometry and cardiac function. To do so will be used 60 Wistar rats divided into 4 group C groups (n = 15) - control; DOX (n = 15) (default feed + DOX intraperitoneal); CCV (n = 15) (added ration of green tea extract + intraperitoneal saline solution); DOX-CV (n = 15) (added ration of green tea extract + DOX intraperitoneal), will be studied 48 hours after administration of doxorubicin. At the end of 48 hours, these animals will be studied by means of echocardiography, biochemical dosages of enzymes of energy metabolism and western blot for evaluation of PPAR alpha, PGC-1 Alpha.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MODESTO, PAMELA N.; POLEGATO, BERTHA F.; DOS SANTOS, PRISCILA P.; GRASSI, LETICIA D. V.; MOLINA, LETICIA C. C.; BAZAN, SILMEIA G. Z.; PEREIRA, ELENIZE J.; FERNANDES, ANA ANGELICA H.; FABRO, ALEXANDRE T.; ANDROCIOLI, VICKELINE N.; ROSCANI, MELIZA G.; DE PAIVA, SERGIO A. R.; ZORNOFF, LEONARDO A. M.; MINICUCCI, MARCOS F.; AZEVEDO, PAULA S. Green Tea (Camellia sinensis) Extract Increased Topoisomerase II beta, Improved Antioxidant Defense, and Attenuated Cardiac Remodeling in an Acute Doxorubicin Toxicity Model. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2021, MAY 5 2021. Web of Science Citations: 0.

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