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Development of green analytical methods to determine the active ingredients of artichoke by HPLC

Grant number: 15/20639-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2015
Effective date (End): July 31, 2018
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Daniel Rinaldo
Grantee:Otávio Aguiar de Souza
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil


Currently, issues related to the environment such as sustainable development and conservation of natural resources are being discussed and dealt often in big events, scientific or not, in various areas of knowledge. In sync, scholars have been developing and applying new techniques whose goals involve reducing the production of toxic substances in industrial and commercial contexts to protect from the environment and the human health. In this context, the preparation and analysis of herbal medicines, as well as their credibility, to the treatment and curing the diseases gain considerable extent, whereas in the chromatographic analysis to determination of principle active in the plant extracts use solvents considered non-green, or causing harmful effects. To the performing these investigations, often employs the High Performance Liquid Chromatography (HPLC). However, this technique uses, in majority of analytical studies, modifiers and highly toxic solvents such as acetonitrile and the trifluoroacetic acid that generate waste that enhance environmental impacts. As order to contribute to the preservation or recovery of the environment, this project aims to develop friendly environmentally methods for analytical determination of active ingredients in Cynara scolymus L. (artichoke) extracts by HPLC. This medicinal specie is present in the National List of Medicinal Plants of interest of the Brazilian Government (Renisus). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SOUZA, OTAVIO AGUIAR; CARNEIRO, RENATO LAJARIM; MARTINS VIEIRA, THIAGO HENRICK; FUNARI, CRISTIANO SOLEO; RINALDO, DANIEL. Fingerprinting Cynara scolymus L. (Artichoke) by Means of a Green Statistically Developed HPLC-PAD Method. FOOD ANALYTICAL METHODS, v. 11, n. 7, SI, p. 1977-1985, . (15/20639-1, 16/08179-8)

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