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Large-scale screening for identification of novel compounds for treatment of HTLV-1 infection and related clinical conditions

Grant number: 15/11566-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2015
Effective date (End): August 31, 2018
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Simone Kashima Haddad
Grantee:Daiane Fernanda dos Santos
Host Institution: Hemocentro de Ribeirão Preto. Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Secretaria da Saúde (São Paulo - Estado). Ribeirão Preto , SP, Brazil
Associated scholarship(s):16/17301-1 - Establishment of a stable HTLV-1-infected reporter cell line for antiviral screening assays, BE.EP.DR

Abstract

It has been estimated that worldwide more than 20 million people are infected by HTLV-1. In Brazil, there are approximately 2.5 million carriers of this virus, which places the country on the first position regarding the absolute number of infected individuals. HTLV-1 is associated with two main clinical diseases: i) adult T-cell (ATLL) leukemia / lymphoma; and ii) progressive myelopathy associated with HTLV-1 /tropical spastic paraparesis (HAM/TSP). Besides this infection is neglected and does not have vaccine, it does not have specific and effective treatment. Therefore, the objective of this project is to analyze 30,000 compounds by High Content Screening technology (HCS) that can identify novel therapeutic agents that may induce apoptosis and /or blocking the viral replication in HTLV-1 infected cells. This study will allow the discovery of new therapeutic options for HTLV-1 treatment. As a consequence, this study will create a support for further pharmaceutical investigations, which it will provide options for treatment and improve the life quality of patients with HTLV-1- induced clinical diseases.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, DAIANE FERNANDA; BAIRROS DE PILGER, DENISE REGINA; VANDERMEULEN, CHARLOTTE; KHOURI, RICARDO; MANTOANI, SUSIMAIRE PEDERSOLI; GONCALVES NUNES, PAULO SERGIO; DE ANDRADE, PETERSON; CARVALHO, IVONE; CASSEB, JORGE; TWIZERE, JEAN-CLAUDE; et al. Non-cytotoxic 1,2,3-triazole tethered fused heterocyclic ring derivatives display Tax protein inhibition and impair HTLV-1 infected cells. Bioorganic & Medicinal Chemistry, v. 28, n. 22, . (15/11566-0, 16/17301-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Daiane Fernanda dos. Screening for identification of new compounds with activity on HTLV-1-infected cell line. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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