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Possible association of intramuscle macrophage content and insulin resistance in mice fed a high fat diet and exercise effects

Grant number: 15/09144-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2015
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Helena Coutinho Franco de Oliveira
Grantee:Jefferson Ferreira Simoura
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Considering that 1) muscle lipid accumulation and inflammation are key events in determining insulin resistance (IR), 2) exercise induces improvements in IR, and 3) hypercholesterolemic LDL receptor knockout (LDLr-/-) mice show no IR improvements after exercise training (unpublished data from our lab), we will investigate the exercise response of high fat diet fed wild type and LDLr-/- mice regarding: 1) muscle lipid content, 2) macrophage content and phenotype and 3) insulin signaling efficiency. (AU)

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