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Effect of exercise on metabolism of fluoride in mice with different susceptibility to dental fluorosis: proteomic analysis.

Grant number: 15/12109-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2015
Effective date (End): May 31, 2018
Field of knowledge:Health Sciences - Dentistry - Social and Preventive Dentistry
Principal Investigator:Marília Afonso Rabelo Buzalaf
Grantee:Mileni da Silva Fernandes
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated scholarship(s):18/06168-4 - Changes in the metabolic profile of kidney in response to exercise after fluoride exposure in mice with different susceptibility to dental fluorosis, BE.EP.PD


Fluoride (F) is an extremely important element in terms of public health due to its properties to prevent or reverse caries in individuals of all ages. It can offer risks to the body if consumed or applied indiscriminately or inappropriately, such as dental fluorosis. After its absorption, F is distributed through the blood stream and stored in calcified tissues and soft tissues, and its excretion is essentially via the kidney. Several molecular mechanisms involving the F metabolism are still unknown. In the last decade, many studies have sought to unravel the influence of genetic factors in genetic susceptibility to dental fluorosis using mouse strains that have very different responses to the effects F. Thus, there is evidence that resistance and susceptibility to fluorosis seem to be influenced by genetic factors as well as the interaction with the environment, such as physical activity, and diet. The current proposal is through proteomics analysis, identify proteins that are altered in kidney and muscle of mice susceptible or resistant to fluorosis in response to changes in exposure F, with and without exercise. Therefore, 60 animals of the strains will be obtained A / J (n = 30) and 129P3 / J (n = 30), susceptible and resistant to fluorosis, respectively. They animals will be divided into six groups according to each treatment, receiving the drinking water containing 0 or 50 ppm F, for 42 days. The groups with physical activity will be held daily races on a treadmill for 60 minutes. After the completion of the treatment, the animals will be euthanized, for collecting samples and conducting analyzes.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERNANDES, MILENI S.; SABINO-ARIAS, ISABELA T.; DIONIZIO, ALINE; FABRICIO, MAYARA F.; TREVIZOL, JULIANA S.; MARTINI, TATIANA; AZEVEDO, LIANE B.; VALENTINE, RUTH A.; MAGUIRE, ANNE; ZOHOORI, FATEMEH, V; et al. Effect of Physical Exercise and Genetic Background on Glucose Homeostasis and Liver/Muscle Proteomes in Mice. METABOLITES, v. 12, n. 2, p. 22-pg., . (16/20020-4, 15/50406-9, 14/50798-1, 15/12109-2)

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