Scholarship 15/08767-4 - Biociências, Neoplasias do cólon

Grant number:	15/08767-4
Support Opportunities:	Scholarships in Brazil - Scientific Initiation
Start date until:	September 01, 2015
End date until:	August 31, 2016
Field of knowledge:	Biological Sciences - Genetics - Mutagenesis

Principal Investigator:	Vinicius Kannen Cardoso
Grantee:	Leticia Mayra de Oliveira Manoel

Host Institution:	Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Associated research grant:	14/06428-5 - Differentiating the effects of epithelial from the neural serotoninergic signalling during inflammation-related colon cancer, AP.JP


Abstract How the serotonergic signaling modulates the colon carcinogenesis remains unclear. 90 C57BL/6 mice will be exposed to the carcinogen azoxymethane (AOM). AOM-exposed mice will be sacrificed at different-time points of the colon carcinogenesis. Colon samples will be analyzed to determine serotonin levels, formation of DNA adducts, and development of aberrant crypt foci (ACF) in the colon tissue. These experiments will provide a timeline view of how serotonin plays a pivotal role in the colonic tissue reaction against a carcinogenic exposure.

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