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Interaction of the activated charcoal with areas of gastric ulceration in horses

Grant number: 15/17195-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2015
Effective date (End): August 31, 2016
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Carla Bargi Belli
Grantee:Miriam Zibordi
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The equine gastric ulceration syndrome has a high prevalence in adult horses and is associated with various clinical manifestations, which brings economic implications and welfare important, especially in animals under training and intense workouts. In recent studies, unpublished, adsorbents drugs, such as activated charcoal, have been used in dogs in cases of gastric ulceration with active bleeding, with good results. The aim of this study is to evaluate the interaction of the adsorption medium (activated charcoal) with gastric ulcers in adult horses, through gastroscopy techniques, biopsy and histological analysis. Six horses older than three years without racial specification, male or female will be used. Initially the induction of gastric ulceration by alternating fasting be performed according to the protocol used by Murray (1994). After that period, assessment is performed gastroscópica animals, where it is observed the presence of lesions (ulcers, peeling, gastritis, etc.) in both aglandular and glandular mucosa in the stomach, as well as subjective evaluation of the percentage displayed mucosa. This assessment will be followed by instillation of the adsorbent product (Captor®) on ulcerative lesions observed. After a period of five minutes of contact with the product lesions, local washing is done and collected biopsy specimens for histological analysis of ulcers. In histopathological evaluation will be observed the interaction of the product with the lesion area, seeking to evidence that the product remains adhered to the ulcer even after washing with water. The re-evaluation of the gastric mucosa of the animal will be held by gastroscopy after a period of three days.

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