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Gene expression of inflammatory cytokine and of microRNA as potential biomarkers of frailty in elderly inserted in a social vulnerability context.

Grant number: 14/21066-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2015
Effective date (End): October 31, 2020
Field of knowledge:Health Sciences - Nursing
Principal Investigator:Márcia Regina Cominetti
Grantee:Carla Manuela Crispim Nascimento
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated scholarship(s):16/19667-3 - Physical exercises and biomarkers of cognitive frailty, BE.EP.PD


Frailty is a condition that often results in the decline of physiological systems and cause vulnerability to adverse conditions because of difficulties to keep homeostasis in situations of exposure to disturbances. The syndrome has been recognized as a significant public health and clinical challenge. Molecular biomarkers directly or indirectly related to the pathophysiology of multiple diseases related to frailty context have been identified. Among them, studies showed changes in immune profiles, as well as deregulation of microRNAs (miRNAs)-related gene expression of molecules involved in the pro-inflammatory activity. This project is a cross-sectional study, based on the assumptions of quantitative research, which aims to determine whether specific markers of chronic low-grade inflammation, as well as for gene expression of miRNA in blood samples are altered in frail elderly subjects. The research will be developed in São Carlos, headquarters of the Federal University of São Carlos (UFSCar). Participants will be invited to participate in the study, older adults living in areas of higher social vulnerability of São Carlos, SP that are on the roof of the Support Center for Family Health (NASF). Biological samples for research subjects will be collected, analyzed and subsequently stored in a biorepository. The whole blood of subjects will be studied by qPCR techniques, by differential expression compared with non-fragile subject. Peripheral concentrations of biomarkers will be determined by enzyme-linked immunosorbent assay (ELISA). Statistical tests of association, regression and diagnostic accuracy will be realized. The results may contribute to the deployment of tools that work in the diagnosis/prevention of frailty syndrome.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO, CARLA M. C.; ZAZZETTA, MARISA S.; GOMES, GRACE A. O.; ORLANDI, FABIANA S.; GRAMANI-SAY, KARINA; VASILCEAC, FERNANDO A.; GRATAO, ALINE C. M.; PAVARINI, SOFIA C. I.; COMINETTI, MARCIA R.. Higher levels of tumor necrosis factor are associated with frailty in socially vulnerable community-dwelling older adults. BMC GERIATRICS, v. 18, . (14/21066-2, 14/50104-0)
MANZINE, PATRICIA R.; VATANABE, IZABELA P.; GRIGOLI, MARINA M.; PEDROSO, RENATA, V; MONTEIRO, MARIA PATRICIA A. O.; OLIVEIRA, DANIELLE S. M. S.; NASCIMENTO, CARLA M. C.; PERON, RAFAELA; ORLANDI, FABIANA S.; COMINETTI, MARCIA R.. Potential Protein Blood-based Biomarkers in Different Types of Dementia: A Therapeutic Overview. CURRENT PHARMACEUTICAL DESIGN, v. 28, n. 14, p. 17-pg., . (19/26709-2, 19/26444-9, 14/21066-2, 21/01906-0, 16/06226-9, 19/02648-4, 17/18808-5, 20/12915-7, 18/05446-0)
FERNANDES MARQUES BIANCO, OTAVIO AUGUSTO; MANZINE, PATRICIA REGINA; CRISPIM NASCIMENTO, CARLA MANUELA; CARVALHO VALE, FRANCISCO ASSIS; IOST PAVARINI, SOFIA CRISTINA; COMINETTI, MARCIA REGINA. Serotoninergic antidepressants positively affect platelet ADAM10 expression in patients with Alzheimer's disease. INTERNATIONAL PSYCHOGERIATRICS, v. 28, n. 6, p. 939-944, . (10/09497-7, 12/01936-7, 14/21066-2, 13/06879-4, 12/08654-7)

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