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Effect of teriparatide (PTH 1-34) in the peri-implant bone repair in rats submitted to orchiectomy: histometric, immunohistochemistry, microtomographic and biomechanical by confocal laser microscopy analysis

Grant number: 15/04649-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Roberta Okamoto
Grantee:Pedro Henrique Silva Gomes Ferreira
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The purpose of this study is to evaluate the peri-implant bone repair in rats submitted to orchiectomy treated with teriparatide. 48 rats will be divided into 3 groups according to the treatment imposed.: SHAM = sham surgery; ORQ = bilateral orchiectomy with no drug treatment and ORQTERI = bilateral orchiectomy, teriparatide treated at a dose of 30 ug / kg / day for 30 days. Each animal will receive two implants being one implant in each tibial metaphysis. Euthanasia will be performed at 72 or 90 days after implant placement. Will be performed the microtomographic (Micro-ct), Histometric by confocal laser microscopy, histologic and immunohistochemistry for immunostaining of proteins that characterize the bone remodeling process (will be evaluated OPG, osteocalcin, RANKL, TRAP) and the Wnt process. Quantitative data will be submitted to statistical test of normality and homogeneous variance being applied a parametric or nonparametric test. For all data a 5% significance level will be considered. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES-FERREIRA, P. H. S.; DE OLIVEIRA, D.; FRIGERIO, P. B.; DE SOUZA BATISTA, F. R.; GRANDFIELD, K.; OKAMOTO, R.. Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats. OSTEOPOROSIS INTERNATIONAL, v. 31, n. 9, . (15/14688-0, 15/04649-7)
GOMES-FERREIRA, PEDRO HENRIQUE SILVA; FRIGERIO, PAULA BUZO; DE MOURA, JULIANA; DUARTE, NATHALIA DANTAS; DE OLIVEIRA, DANILA; DEERING, JOSEPH; GRANDFIELD, KATHRYN; OKAMOTO, ROBERTA. Evaluation of Vitamin D isolated or Associated with Teriparatide in Peri-Implant Bone Repair in Tibia of Orchiectomized Rats. BIOLOGY-BASEL, v. 12, n. 2, p. 14-pg., . (15/04649-7, 15/14688-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FERREIRA, Pedro Henrique Silva Gomes. Effect of teriparatide (PTH 1-34) on peri-implantar bone repair in orchiectomized rats. 2017. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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