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Vaccination of sheep against Haemonchus contortus

Grant number: 15/00221-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2015
Effective date (End): August 31, 2017
Field of knowledge:Biological Sciences - Parasitology - Helminthology of Parasites
Principal researcher:Alessandro Francisco Talamini Do Amarante
Grantee:César Cristiano Bassetto
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Two trials will be carried out to assess the efficacy of a vaccine against Haemonchus contortus in sheep. Experiment 1 aims to assess the effectiveness of the vaccine in ewes during the pregnancy and lactation periods, maintained with high or low nutritional level. These ewes will be divided into four groups as follows: Group 1: immunised with the vaccine against haemonchosis and maintained with a high nutritional level; Group 2: control maintained with a high nutritional level; Group 3: immunised with the vaccine against haemonchosis and maintained with a low nutritional level and Group 4: Control maintained with a low nutritional level. The experiment 2 will evaluate the efficacy of the vaccine in commercial farms that rise different sheep breeds and presenting different management conditions to assess the contribution of the vaccine in the prophylaxis of nematode infections in "real" situations. In both trials, ewes and lambs will be trialled. Vaccinated groups will receive glycoproteins extracted from the gut of H. contortus (5 g each dose) diluted in saponin adjuvant (1 mg each dose) and the control groups will receive only the adjuvant. The ewes will be vaccinated every three weeks from the beginning of pregnancy until weaning of lambs. The lambs will be vaccinated with the same frequency from the third week until they complete five months of age. In both trials, parasitological, haematological and immunological tests will be performed.

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALEXANDRE DE ALBUQUERQUE, ANA CLAUDIA; BASSETTO, CESAR CRISTIANO; DE ALMEIDA, FABIANA ALVES; AMARANTE, ALESSANDRO F. T.. Development of Haemonchus contortus resistance in sheep under suppressive or targeted selective treatment with monepantel. Veterinary Parasitology, v. 246, p. 112-117, . (15/25718-7, 15/00221-2)
BASSETTO, C. C.; ALMEIDA, F. A.; NEWLANDS, G. F. J.; SMITH, W. D.; CASTILHOS, A. M.; FERNANDES, S.; SIQUEIRA, E. R.; AMARANTE, A. F. T.. Trials with the Haemonchus vaccine, Barbervax (R), in ewes and lambs in a tropical environment: Nutrient supplementation improves protection in periparturient ewes. Veterinary Parasitology, v. 264, p. 52-57, . (15/25718-7, 15/00221-2)
TEIXEIRA, MARCEL; IGOR MAGALHAES MATOS, ANTONIO FRANCISCO; ALBUQUERQUE, FERNANDO HENRIQUE M. A.; BASSETTO, CESAR CRISTIANO; SMITH, WILLIAM DAVID; MONTEIRO, JOMAR PATRICIO. Strategic vaccination of hair sheep against Haemonchus contortus. Parasitology Research, v. 118, n. 8, p. 2383-2388, . (15/00221-2)
ALMEIDA, FABIANA A.; ALBUQUERQUE, ANA CLAUDIA A.; BASSETTO, CESAR C.; STARLING, RENAN Z. C.; LINS, JOSE GABRIEL G.; AMARANTE, ALESSANDRO F. T.. Long spelling periods are required for pasture to become free of contamination by infective larvae of Haemonchus contortus in a humid subtropical climate of Sao Paulo state, Brazil. Veterinary Parasitology, v. 279, . (15/25718-7, 15/00221-2)
BASSETTO, CESAR C.; ALMEIDA, FABIANA A.; NEWLANDS, GEORGE F. J.; SMITH, W. DAVID; AMARANTE, ALESSANDRO F. T.. Repeated vaccination against Haemonchus contortus provides continuous protection to young grazing sheep. Veterinary Parasitology, v. 287, . (15/00221-2, 15/25718-7)
ALBUQUERQUE, ANA CLAUDIA A.; BASSETTO, CESAR CRISTIANO; ALMEIDA, FABIANA A.; HILDERSLEY, KATIE A.; MCNEILLY, TOM N.; BRITTON, COLLETTE; AMARANTE, ALESSANDRO F. T.. Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens. VETERINARY RESEARCH, v. 50, n. 1, . (15/25718-7, 15/00221-2)
AMARANTE, M. R. V.; SANTOS, M. C.; BASSETTO, C. C.; AMARANTE, A. F. T.. PCR primers for straightforward differentiation of Haemonchus contortus, Haemonchus placei and their hybrids. JOURNAL OF HELMINTHOLOGY, v. 91, n. 6, p. 757-761, . (14/02305-6, 15/00221-2, 12/23941-2)

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