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Phytochemical study of stems from Arrabidaea brachypoda and pharmacological evaluation in Zebrafish (Danio rerio) models

Grant number: 15/14002-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2015
Effective date (End): December 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Wagner Vilegas
Grantee:Pollyana Hammoud Dias
Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil


The Brazilian biodiversity provides a lush and extensive route of discovery for the natural products industry. It is the Brazilian cerrado is the Arrabidaea brachypoda species, also known as "cipó una" or "cervejinha do campo". Where through an infusion of the root, the extract obtained is popularly used for kidney stones and signs of inflammation. Its effective anti-inflammatory, analgesic, anti-parasitic and anti-tumor has been described in the literature, but scientific reports on this species remain scarce. The compounds isolated yet root differ from any previously described, and they fit into a rare group of dimeric flavonoids, which makes the further study of this promising species. (ROCHA et al., 2014).The proposed scientific research linked to the post-doctoral project "Arrabidaea spp: studies to make possible the development of phytomedicines", aims to identify phytochemical constituents of the stems collected from Arrabidaea brachypoda, to enable a new source of secondary metabolites already isolated root, and identify other compounds that are not present in leaves and roots of this species. In a second stage, performing in the crude extract, fractions and pure compounds toxicological tests through the Zebrafish model on an already implemented platform in our research group.

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