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Influence of gender in adjustments hemodynamic and neuroimmune induced by dynamic resistance training in experimental model of hypertension

Grant number: 15/10329-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2015
Effective date (End): December 31, 2016
Field of knowledge:Health Sciences - Physical Education
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Kátia de Angelis Lobo D Avila
Grantee:Amanda Aparecida de Araujo
Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil


Cardiovascular diseases are the leading cause of death worldwide. Among the risk factors that lead to the development of these diseases, hypertension has a high prevalence in both sexes. Regular exercise, especially aerobic dynamic, has been recommended as nonpharmacological conduct in the management of cardiac patients. However, the effects of resistance exercise training in hypertensive subjects remains understudied. In this sense, the present study aims to investigate the influence of gender on hemodynamic and autonomic adaptations, oxidative stress and inflammation induced by dynamic resistance exercise training of moderate intensity on a model of arterial hypertension. To this end, 32 spontaneously hypertensive rats (SHR) will be divided into 4 groups (n = 8 each): sedentary females (FS) and males (MS) - will be followed for eight weeks; trained females (FT) and males (MT) - will be submitted to resistance training for 8 weeks; The animals will be trained in adapted ladder with moderate intensity (40-60% of maximum load) for eight weeks. At the end of exercise training period will be assessed: physical capacity, activity of cintrato synthase and phosphofructokinase enzymes and the type of muscle fiber; blood pressure and heart rate; baroreflex sensitivity and cardiac autonomic modulation and vascular function; oxidative stress (lipid peroxidation; carbolinyl protein, superoxide anion and hydrogen peroxide; catalase, total antioxidant capacity, superoxide dismutase and glutathione peroxidase, glutathione redox balance (GSH/GSSG); Nitric oxide bioavailability (concentration of nitrites and nitrates) and inflammatory mediators (TNF alpha, IL_1beta, IL-6 and IL-10). (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARAUJO, AMANDA; DIAS, DANIELLE; BERNARDES, NATHALIA; CONTI, FILIPE; ALLIONI, GABRIELA; IRIGOYEN, MARIA CLAUDIA; DE ANGELIS, KATIA. Dynamic resistance training improves cardiovascular autonomic variability in male hypertensive rats. FASEB JOURNAL, v. 31, p. 1-pg., . (15/10329-5, 15/11223-6)
SHECAIRA, TANIA; DE ARAUJO, AMANDA; MESQUITA, FREDERICO; ALLIONI, GABRIELA; PAIXAO, CAMILA; DIAS, DANIELLE; STOYELL-CONTI, FELIPE; BERNARDES, NATHALIA; DE ANGELIS, KATIA. Dynamic resistance training attenuate cardiac and renal oxidative stress profile in spontaneously hypertensive male rats. FASEB JOURNAL, v. 34, p. 2-pg., . (15/10329-5)
DE ARAUJO, AMANDA APARECIDA; DIAS, DANIELLE DA SILVA; ALLIONI, GABRIELA ABRAHAO; BERNARDES, NATHALIA; IRIGOYEN, MARIA CLAUDIA; DE ANGELIS, KATIA. Positive Role of Dynamic Resistance Training in the Management of Renal Oxidative Stress in Female Hypertensive Rats. FASEB JOURNAL, v. 33, p. 2-pg., . (15/10329-5)
ARAUJO, AMANDA; BERNARDES, NATHALIA; DIAS, DANIELLE; MELLO, TAFNE; COSTA, GABRIELLY; BRITO, JANAINA; IRIGOYEN, MARIA CLAUDIA; DE ANGELIS, KATIA. Moderate Intensity Dynamic Resistance Training Induced Cardiovascular Benefits in Female Hypertensive Rats. FASEB JOURNAL, v. 30, p. 2-pg., . (15/10329-5)

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