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Genomic analysis of the xylanolytic yeast Pseudozyma brasiliensis

Grant number: 14/15799-7
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2015
Effective date (End): November 30, 2017
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal researcher:Gustavo Henrique Goldman
Grantee:Renato Augusto Corrêa dos Santos
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated scholarship(s):16/13968-1 - Improvement of the metabolic network reconstruction of Kalmanozyma brasiliensis and associated metabolic simulations, BE.EP.MS


Brazil is responsible for 33% of the biethanol production in the world and dominates the technology for its production using hexoses and their dissacharides available in sugarcane. The use of pentoses present in lignocellulosic biomass, as in sugarcane bagasse, is a promising option for production of second generation bioethanol. However, industrial strains of Saccharomyces cerevisiae usually employed in the ethanolic fermentation process are naturally not able to ferment these sugars efficiently. The family Ustilaginaceae (Basidiomycota) has members with high biotechnological potential, including the yeasts of the genus Pseudozyma. Recently, our group isolated the strain Pseudozyma brasiliensis GHG001, producing a xylanase with high potential of xylan hydrolysis, as well as capacity of growth in xylose and xylan as unique carbon sources. Thus, this yeast is promising as source of genes and pathways for constructing recombinant S. cerevisiae. The aims of this work are (i) improvement of the genome annotation of P. brasiliensis GHG001, (ii) study comparative genomics of P. brasiliensis with other members of Ustilaginaceae, especially the gene families involved in biomass hydrolysis, pentose catabolism, oxidation-reduction and isomerization, including the genome of four Pseudozyma isolates already sequenced in our lab, (iii) the reconstruction of a draft of metabolic networks in P. brasiliensis, and (iv) in silico exploitation of interesting pathways using flux balance analysis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BORIN, GUSTAVO PAGOTTO; SANCHEZ, CAMILA CRISTINA; DE SANTANA, ELIANE SILVA; ZANINI, GUILHERME KEPPE; CORREA DOS SANTOS, RENATO AUGUSTO; PONTES, ANGELICA DE OLIVEIRA; DE SOUZA, ALINE TIEPPO; TAVARES SOARES DAL'MAS, ROBERTA MARIA MENEGALDO; RIANO-PACHON, DIEGO MAURICIO; GOLDMAN, GUSTAVO HENRIQUE; et al. Comparative transcriptome analysis reveals different strategies for degradation of steam-exploded sugarcane bagasse by Aspergillus niger and Trichoderma reesei. BMC Genomics, v. 18, . (14/15799-7, 15/08222-8, 11/08945-9, 14/11766-7, 13/09541-4, 14/11733-1)
BONIN, GUSTAVO PAGOTTO; CARAZZOLLE, MARCELO FALSARELLA; CORREA DOS SANTOS, RENATO AUGUSTO; RIANO-PACHON, DIEGO MAURICIO; DE CASTRO OLIVEIRA, JULIANA VELASCO. Gene Co-expression Network Reveals Potential New Genes Related to Sugarcane Bagasse Degradation in Trichoderma reesei RUT-30. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 6, . (14/11766-7, 17/18987-7, 15/08222-8, 14/15799-7)
CORREA DOS SANTOS, RENATO AUGUSTO; GOLDMAN, GUSTAVO HENRIQUE; RIANO-PACHON, DIEGO MAURICIO. ploidyNGS: visually exploring ploidy with Next Generation Sequencing data. Bioinformatics, v. 33, n. 16, p. 2575-2576, . (14/15799-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Renato Augusto Corrêa dos. Genomic analysis of the xylanolytic yeast Pseudozyma brasiliensis GHG001. 2018. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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