Cytomegalovirus (CMV) is a DNA, double stranded virus. After the primary infection the virus remains latent in the body but can reactivate in cases of immunosuppression, such as pregnancy, chemotherapy and AIDS. Currently, CMV is the leading cause of congenital infection in developed countries, causing significant injuries to the fetus, like deafness and neurological impairment. The virus is widely distributed among human populations and its transmission is related to socioeconomical and hygienic conditions, varying among developed and developing countries. The vertical transmission is rather rare in "non - primary" infections, but in primary infections the transmission rate can be as high as 40%. In Brazil information concerning CMV seroprevalence is scarce, especially during pregnancy. The present work aims to evaluate the prevalence of past or current infections in pregnant women in the metropolitan area of Sao Paulo - Brazil, referred to a major clinical laboratory for pre-natal testing, independent of clinical suspicion of the disease.
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