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Study of sleep and biological rhythms as predictors of conversion, response to treatment and progression of psychoses

Grant number: 15/09421-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2015
Effective date (End): May 31, 2016
Field of knowledge:Health Sciences - Medicine - Psychiatry
Cooperation agreement: CNPq - Pronex
Principal researcher:Rodrigo Affonseca Bressan
Grantee:Bruno da Silva Brandão Gonçalves
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention, AP.TEM


Polysomnographic studies involving subjects with schizophrenia have reported the continuity of sleep disturbances, decreased slow-wave sleep, a reduction in the latency of REM sleep, increased the percentage of REM sleep and reducing the amount of NREM sleep in minutes. As for the polysomnographic findings in TB, the main feature seems to be the reduction of total sleep time. The atypical antipsychotic class of drugs with established efficacy in the treatment of schizophrenia and TB significantly increase total sleep time and stage 2 in particular. But usually persists even in sleep changes during treatment. Different sources of evidence have suggested that abnormalities in neuroplasticity play an important role in the pathophysiology of schizophrenia and TB. Interestingly, recent studies have demonstrated a role of sleep on cognition and brain neuroplasticity. Studies addressing sleep in schizophrenia and TB are rare and the results often subject to bias arising from the use of various medications, comorbidities or stages of the disease. To our knowledge, there are no studies evaluating whether changes in sleep or sleep-wake cycle could predict the development of psychosis and TB in individuals with EMR. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BRUNO GONÇALVES; JULIANA CASTRO; MÁRCIO A. ZANINI; LIA BITTENCOURT; ARY GADELHA; GRACCIELLE R. CUNHA; FERNANDO M. COELHO; SERGIO TUFIK; RODRIGO A. BRESSAN; ELISA BRIETZKE. Circadian rhythm disturbances and conversion to psychosis in ultra high-risk youth. Revista Brasileira de Psiquiatria, v. 38, n. 2, p. 178-179, Jun. 2016.

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