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Effects of exercise training on bone parameters in patients subjected to bariatric surgery: a randomized controlled clinical trial

Grant number: 15/02833-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2015
Effective date (End): May 31, 2019
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Bruno Gualano
Grantee:Igor Hisashi Murai
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Obesity is considered as a medical condition characterized mainly by excessive accumulation of body fat. Currently, this condition is a global public health problem, whose prevalence has increased significantly. In Brazil, the term is used to define morbid obesity extreme cases, classified, therefore, as a BMI e 40 kg / m2 or greater than 35 kg / m2 with clinical comorbidities associated. Obesity has become a global epidemic in different age groups, with approximately 500 million obese subjects worldwide. Even more, it is estimated that the number of subjects with morbid obesity has increased fivefold in the last 15 years. Bariatric surgery is considered today one of the main treatments for morbid obesity due to rapid induction of weight loss and improvement of comorbidities associated with this condition. Despite the beneficial effects caused by bariatric surgery, some adverse effects are consistently reported in the postoperative period, especially in relation to bone tissue. In this context, exercise training appears to be a potentially interesting strategy in preventing bone loss in these patients. It is known that mechanical stimuli provided by the exercise promote positive effects on bone, resulting the maintenance and increased bone mass and preventing deterioration of the microarchitecture of that tissue. Despite the existence of studies that support the beneficial role of exercise training on bone parameters in healthy subjects and those with low bone mass, no controlled clinical, randomized trials, have evaluated the effects of exercise training on bone tissue in patients undergoing bariatric surgery and its possible preventive role in the deterioration of the tissue. Thus, the use of methods considered the gold standard for evaluating bone parameters at the structural level, as well as recurrent bone markers in clinical investigations, are of great importance to elucidate the research questions in this project. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MURAI, IGOR H.; ROSCHEL, HAMILTON; DANTAS, WAGNER S.; GIL, SAULO; MEREGE-FILHO, CARLOS; DE CLEVA, ROBERTO; DE SA-PINTO, ANA L.; LIMA, FERNANDA; SANTO, MARCO A.; BENATTI, FABIANA B.; KIRWAN, JOHN P.; PEREIRA, ROSA M.; GUALANO, BRUNO. Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 104, n. 10, p. 4639-4650, OCT 2019. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MURAI, Igor Hisashi. Exercise training as a treatment to attenuate bone loss in women underwent Roux-en-Y gastric bypass: a randomized controlled trial. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.

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