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Study on the synthesis of maculalactone derivatives

Grant number: 15/05454-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2015
Effective date (End): December 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Paulo Marcos Donate
Grantee:Mayla Eduarda Rosa Celorio
Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


This research project is a subproject which is already being developed in our laboratory with financial aid of FAPESP (Process 2013/18254-9) and want to use multicomponent processes to synthesize derivatives of maculalactonas. Initially, it is intended to use multicomponent synthetic procedures already described in literature, and further improved in our laboratory using heating by microwave irradiation, in the synthesis of maculalactonas derivatives, which are natural products with biological activity. The synthesized products will be purified and have their structures adequately elucidated by various spectroscopic methods. Subsequently, the obtained compounds may be subjected to various kinds of biological assays.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PREVIDI, DANIEL; ROSA, MAYLA EDUARDA; DONATE, PAULO MARCOS. Fast and Efficient Synthesis of Maculalactone Derivatives via the Micro-wave Technique. CURRENT MICROWAVE CHEMISTRY, v. 4, n. 3, p. 229-237, . (13/18254-9, 15/05454-5, 16/04896-7)
PREVIDI, DANIEL; NARDINI, VIVIANI; ROSA, MAYLA EDUARDA; PALARETTI, VINICIUS; JOSE DA SILVA, GIL VALDO; DONATE, PAULO MARCOS. Stereochemical assignment of four diastereoisomers of a maculalactone derivative by computational NMR calculations. Journal of Molecular Structure, v. 1178, p. 467-478, . (13/18254-9, 15/05454-5, 16/04896-7)

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