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Preparation, evaluation and separation optimization of porous-layer open-tubular (PLOT)columns for nano-LC-MS/MS analysis of sulfonamides and their acetylated metabolites in food samples

Grant number: 15/12306-2
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 30, 2015
Effective date (End): September 29, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Fernando Mauro Lanças
Grantee:Meire Ribeiro da Silva
Supervisor abroad: Elsa Lundanes
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Research place: University of Oslo (UiO), Norway  
Associated to the scholarship:12/22055-9 - Development of silica modified with ionic liquids and their use in sample preparation techniques, BP.DR


The presence of antibiotic residues such as sulfonamides in milk interferes with the manufacture of some dairy products, may cause allergic reactions in humans, as well as antibiotic resistance. The antibiotic metabolites residues can be even more hazardous and more persistent than the original compounds. Along the years the definition of ''residue'' of many contaminants have been modified and some regulatory agencies have been included the contaminant metabolites in their maximum residue limits (LMR). In this context residue monitoring of antibiotics and their metabolites in food sample is an important activity to guarantee the safety of food. In order to monitoring sulfonamides and their acetylated metabolites in milk samples to get separation efficiency and lower limit of the detection (LOD), studies will be undertaken employing high efficiency porous layer open tubular (PLOT) columns and also separation techniques coupled to tandem mass spectrometry in a nano -LC (PLOT) - MS/MS set up. After the analytical method development and validation the system will be employed in the analysis of sulfonamides in real food samples. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMINGUES NAZARIO, CARLOS EDUARDO; FUMES, BRUNO HENRIQUE; DA SILVA, MEIRE RIBEIRO; LANCAS, FERNANDO MAURO. New materials for sample preparation techniques in bioanalysis. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1043, p. 81-95, . (12/22055-9, 14/07347-9, 15/15462-5, 15/12306-2)
DA SILVA, MEIRE RIBEIRO; BRANDTZAEG, OLE KRISTIAN; VEHUS, TORE; LANCAS, FERNANDO MAURO; WILSON, STEVEN RAY; LUNDANES, ELSA. An automated and self-cleaning nano liquid chromatography mass spectrometry platform featuring an open tubular multi-hole crystal fiber solid phase extraction column and an open tubular separation column. Journal of Chromatography A, v. 1518, p. 104-110, . (15/12306-2)

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