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Semi-automatic classification of vertebral compression fractures using shape techniques of image processing in magnetic resonance imaging.

Grant number: 15/08778-6
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): September 14, 2015
Effective date (End): December 20, 2015
Field of knowledge:Health Sciences - Medicine - Medical Radiology
Principal Investigator:Marcello Henrique Nogueira Barbosa
Grantee:Lucas Frighetto Pereira
Supervisor: Rangaraj Mandayam Rangayyan
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: University of Calgary, Canada  
Associated to the scholarship:14/12135-0 - Semiautomatic classification of benign and malignant vertebral fractures in magnetic resonance imaging, BP.MS


The aim of this project is to apply specific medical image-processing techniques previously developed by the research team at the University of Calgary, to the computer-aided diagnosis system (CAD) of vertebral compression fractures (VCFs) in magnetic resonance imaging (MRI). This will provide a different analysis to complement the already implemented techniques in my post-graduation project "Semi-automatic classification of benign and malignant vertebral fractures in magnetic resonance imaging". As part of my Master´s project, we included 63 patients (38 women, 25 men, mean age 62.25 ± 14.13 years) with 103 vertebral bodies with VCFs and 106 without VCFs. Each one of these 209 vertebral bodies were manually segmented using the T1-weighted central sagittal slice lumbar spine MRI. F. To date we implemented image processing techniques to extract and analyze texture and contrast attributes. We evaluated the 14 attributes of Haralick and, as a contrast attributes, we used the calculation of coefficient of variation, skewness and kurtosis of gray level histogram. Tests using the classifier k-nearest neighbor (KNN) with k = 3, 10-folds cross-validation after selecting attributes reached an area under the ROC curve (AUROC) of 0.913 for the classification between benign and malignant VCFs. The techniques to be added on the current project are the calculation of compactness, convex deficiency, central invariant moments and Fourier descriptor of the vertebral bodies. These are shape analyses calculations and our hypothesis is that they may aid in the classification of the compression fractures of vertebral bodies.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRIGHETTO-PEREIRA, LUCAS; RANGAYYAN, RANGARAJ MANDAYAM; METZNER, GUILHERME AUGUSTO; DE AZEVEDO-MARQUES, PAULO MAZZONCINI; NOGUEIRA-BARBOSA, MARCELLO HENRIQUE. Shape, texture and statistical features for classification of benign and malignant vertebral compression fractures in magnetic resonance images. COMPUTERS IN BIOLOGY AND MEDICINE, v. 73, p. 147-156, . (15/08778-6, 14/12135-0)

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