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Role of autophagy in the control of infection by Trypanosoma cruzi and the influence of the innate immunity receptors in this process

Grant number: 15/09568-5
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2015
Effective date (End): July 31, 2018
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Karina Ramalho Bortoluci
Grantee:Kely Catarine Matteucci
Host Institution: Centro de Terapia Celular e Molecular. Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


The autophagy is a homeostatic process cell, where misfolded proteins and damaged organelles are degraded. The autophagy can also be enabled when there is a lack of nutrients or lack of energy (ATP), degrading macromolecules to suppress the lack of these components. In infectious processes, the autophagy helps in the control of microorganisms, which are involved by autophagosomes that fuse to lysosomes, responsible for degradation of the captured microorganism. The molecular Pattern Recognition Receptors (PRRs) of innate immunity are being related to the regulation of autophagy. In this sense, the Toll-Like Receptors (TLRs) activate the process of autophagy, while the role of the cytosolic complexes, the inflammasomes, is still controversial and needs to be better elucidated. Since both the TLRs receptors as the inflammassomes are involved in activation of effector mechanisms for the control of Trypanosoma cruzi, the proposal of this project is to study the role of autophagy as possible effector mechanism for the control of the Trypanosoma cruzi and assess the influence of PRRs in regulation this process. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HERNANDEZ-TORRES, MARCELA; DO NASCIMENTO, SILVA ROGERIO; REBOUCAS, MONICA CARDOZO; CASSADO, ALEXANDRA; MATTEUCCI, KELY CATARINE; D'IMPERIO-LIMA, MARIA REGINA; VASCONCELOS, JOSE RONNIE C.; BORTOLUCI, KARINA R.; ALVAREZ, JOSE MARIA; AMARANTE-MENDES, GUSTAVO P.. Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection (vol 12, 817, 2021). CELL DEATH & DISEASE, v. 12, n. 9, p. 1-pg., . (15/20432-8, 15/09568-5, 18/15607-1, 17/25942-0, 18/25984-7, 16/24912-7, 12/24737-0)
AMARANTE-MENDES, GUSTAVO P.; RANA, AAMIR; DATOGUIA, TARCILA SANTOS; HAMERSCHLAK, NELSON; BRUMATTI, GABRIELA. CR-ABL1 Tyrosine Kinase Complex Signaling Transduction: Challenges to Overcome Resistance in Chronic Myeloid Leukemi. HARMACEUTIC, v. 14, n. 1, . (15/09568-5, 18/25395-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MATTEUCCI, Kely Catarine. The role of NLRP3 in the control of autophagy during T. cruzi infection. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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