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Development of biosensors for instantaneous detection of proteins and cancer cells, for application on on-site biopsy

Grant number: 15/04929-0
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2015
Effective date (End): June 30, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Cátia Cristina Capêlo Ornelas Megiatto
Grantee:Diego Luan Bertuzzi
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):17/24630-4 - Synthesis and self-assembly of hybrid dendrimer/linear block copolymers containing folates for applications in biosensors and drug delivery systems, BE.EP.DD


In some malignant tumors, cancer cells overexpress specific receptors such as FOLR1 protein. FOLR1 is responsible for the physiological transport of folic acid, which binds strongly to the protein in order to be transported to the intracellular medium. In this project we propose the development of a biosensor based on the interaction FOLR1-folic acid, for instantaneous detection of tumor cells on on-site biopsy. This sensor would allow for early diagnosis of malignant tumors and increase of patient survival. The initial phase of the project will be dedicated to the synthesis of ferrocenyl derivatives of folic acid. Using the ferrocene as redox probe, cyclic voltammetry will be used to study the supramolecular interactions between the folic acid-ferrocene molecules and the protein FOLR1. The second phase of the project consists on the immobilization of polymeric folic acid-ferrocene structures on platinum and carbon electrode surfaces through adsorption. Moreover, thiol groups will be used to modify gold electrodes with folic acid-ferrocene moieties. The last phase of the project will be dedicated to an extensive electrochemical study on the new modified electrodes, in order to optimize their electrochemical response and develop fast and efficient biosensors. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BERTUZZI, DIEGO L.; BECHER, TIAGO B.; CAPRETI, NAYLIL M. R.; AMORIM, JULIO; JURBERG, IGOR D.; MEGIATTO, JR., JACKSON D.; ORNELAS, CATIA. General Protocol to Obtain D-Glucosamine from Biomass Residues: Shrimp Shells, Cicada Sloughs and Cockroaches. GLOBAL CHALLENGES, v. 2, n. 11, . (18/02093-0, 15/04929-0, 17/24017-0, 14/15718-7, 13/22160-0)
GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; DA SILVA, LAURA C. E.; DE OLIVEIRA, MARCELO G.; ORNELAS, CATIA. Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity. ACS APPLIED POLYMER MATERIALS, v. 2, n. 5, p. 2027-2034, . (18/14142-5, 18/02093-0, 15/23761-2, 15/04929-0, 16/02414-5)
BECHER, TIAGO B.; BRAGA, CAROLYNE B.; BERTUZZI, DIEGO L.; RAMOS, JR., MIGUEL D.; HASSAN, AYAZ; CRESPILHO, FRANK N.; ORNELAS, CATIA. The structure-property relationship in LAPONITE (R) materials: from Wigner glasses to strong self-healing hydrogels formed by non-covalent interactions. SOFT MATTER, v. 15, n. 6, p. 1278-1289, . (13/11519-7, 15/16672-3, 18/02093-0, 13/14262-7, 16/25806-6, 15/04929-0)
GARZON-PORRAS, ANA M.; BERTUZZI, DIEGO L.; LUCAS, KURT; ORNELAS, CATIA. Anti-inflammatory activity of polyamide dendrimers bearing bile acid termini synthesized via SPAAC. JOURNAL OF NANOPARTICLE RESEARCH, v. 21, n. 11, . (18/02093-0, 15/04929-0)
BERTUZZI, DIEGO L.; PERLI, GABRIEL; BRAGA, CAROLYNE B.; ORNELAS, CATIA. Synthesis, characterization, and anticancer activity of folate gamma-ferrocenyl conjugatest. NEW JOURNAL OF CHEMISTRY, v. 44, n. 12, p. 4694-4703, . (18/02093-0, 15/04929-0, 17/06146-8)

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