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Evaluation of let7 and lin28 and the related effects on glucose homeostasis in offspring from obese dams

Grant number: 15/01947-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2015
Effective date (End): January 17, 2020
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Adriana Souza Torsoni
Grantee:Laís Angélica de Paula Simino
Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil


In recent decades, obesity has acquired epidemic characteristics and among women this disease becomes more worrisome. Arising from changes in embryonic development and lactation period, as lack or excess of nutrients can lead to a phenomenon known as metabolic programming. Epigenetics has been demonstrated as an important factor that links the intrauterine environment and the offspring metabolism. Among the existing epigenetic modifications, microRNAs play a key role, participating in post-transcriptional regulation of several proteins. Let-7 microRNA was one of the first to be discovered and recent studies have pointed out the possible participation of Let-7 in energy homeostasis. Lin28 is a protein that modulates the expression of this miRNA. The overexpression of Lin28 and decrease of Let-7 in animal model is able to increase the uptake of glucose by improving insulin signaling, involving PI3K and m-TOR, besides of decreasing fat mass and improving sensitivity to insulin in peripheral tissues. Therefore, our goal is to investigate the hypothesis that maternal obesity modulates the Let-7 expression and Lin-28 in the offspring and that this modulation may be responsible for changes in glucose homeostasis and oxidative metabolism in offspring of obese dams. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE PAULA SIMINO, LAIS ANGELICA; PANZARIN, CAROLINA; TORSONI, MARCIO ALBERTO; IGNACIO-SOUZA, LETICIA MARTINS; MILANSKI, MARCIANE; TORSONI, ADRIANA SOUZA. Maternal resistance to diet-induced obesity partially protects newborn and post-weaning male mice offspring from metabolic disturbances. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 12, n. 4, p. 660-670, . (15/01947-7)
SIMINO, LAIS A. P.; PANZARIN, CAROLINA; FONTANA, MARINA F.; DE FANTE, THAIS; GERALDO, MURILO V.; IGNACIO-SOUZA, LETICIA M.; MILANSKI, MARCIANE; TORSONI, MARCIO A.; ROSS, MICHAEL G.; DESAI, MINA; et al. MicroRNA Let-7 targets AMPK and impairs hepatic lipid metabolism in offspring of maternal obese pregnancies. SCIENTIFIC REPORTS, v. 11, n. 1, . (15/01947-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SIMINO, Laís Angélica de Paula. Hepatic Let-7 modulation and the effects on energy homeostasis on offspring programmed by maternal obesity. 2020. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas Limeira, SP.

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