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Involvement of the NF-kB and PPAR-gamma in inflammatory and metabolic response in monocytes of sedentary, physically active and trained individuals

Grant number: 14/08003-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2015
Effective date (End): December 31, 2018
Field of knowledge:Health Sciences - Physical Education
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Fábio Santos de Lira
Grantee:Barbara de Moura Mello Antunes
Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Associated scholarship(s):16/12369-7 - Impact of two dietary models on metabolic, inflammatory and genetic parameters in individuals of different physical fitness conditions, BE.EP.DR


The sedentary lifestyle is associated with the box dyslipidemia, chronic low-grade inflammation and excess weight. Faced with this question, we hypothesized that inflammatory and metabolic changes, systemic and tissue, is favor to installation and progression of several metabolic abnormalities, and are directly involved with the training status. We suggest the involvement of gene transcription factors coordinating such changes, such as peroxisome proliferator -activated gamma (PPAR - ³) and nuclear factor kappa B receptors (NF-kB). The objective of this project is to analyze the immuno-metabolic response of subjects under different conditions of physical training (sedentary, physically active and trained). A better understanding of the mechanisms involved in immune - metabolic response, due to the physical condition, have a direct impact on the elucidation of the issues related to dyslipidemia, as well as the development of new therapies that target intracellular pathways involved in inflammatory processes. To test that hypothesis, will be recruited 30 male subjects, eutrophic, aged between 18 and 30 years, and will be divided into three groups according to aerobic fitness : Sedentary, physically active and Trained. The project will answer two questions: 1) Evaluate the behavior of plasma inflammatory and metabolic parameters during acute aerobic exercise on different groups in the three domains of intensity (moderate, heavy and severe) on a cycle ergometer; 2) Assess the gene expression and activation of gene transcription factors, PPAR - ³ and NF-kB in monocytes (in vitro) of different groups by checking their contributions in immuno- metabolic response according to the presence or absence of agonists and antagonists specific. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANTUNES, BARBARA MOURA; ROSSI, FABRICIO EDUARDO; TEIXEIRA, ANA MARIA; LIRA, FABIO SANTOS. Short-time high-intensity exercise increases peripheral BDNF in a physical fitness-dependent way in healthy men. European Journal of Sport Science, v. 20, n. 1, . (14/08003-1)
ANTUNES, B. M.; CAMPOS, E. Z.; PARMEZZANI, S. S.; SANTOS, R. V.; FRANCHINI, E.; LIRA, F. S.. Sleep quality and duration are associated with performance in maximal incremental test. Physiology & Behavior, v. 177, p. 252-256, . (14/08003-1)
SANCHES SILVEIRA, LOREANA; MELLO ANTUNES, BARBARA DE MOURA; ARAUJO MINARI, ANDRE LUIS; THOMATIELI DOS SANTOS, RONALDO VAGNER; ROSA NETO, JOSE CESAR; LIRA, FABIO SANTOS. Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, v. 26, n. 2, p. 115-132, . (14/08003-1, 13/25310-2, 13/09367-4, 14/01246-6)
ANTUNES, BARBARA MOURA; CAMPOS, EDUARDO ZAPATERRA; THOMATIELI DOS SANTOS, RONALDO VAGNER; ROSA-NETO, JOSE CESAR; FRANCHINI, EMERSON; BISHOP, NICOLETTE C.; LIRA, FABIO SANTOS. Anti-inflammatory response to acute exercise is related with intensity and physical fitness. Journal of Cellular Biochemistry, v. 120, n. 4, p. 5333-5342, . (14/08003-1)
ANTUNES, B. M.; ROSSI, F. E.; OYAMA, L. M.; ROSA-NETO, J. C.; LIRA, F. S.. Exercise intensity and physical fitness modulate lipoproteins profile during acute aerobic exercise session. SCIENTIFIC REPORTS, v. 10, n. 1, . (14/08003-1)
DORNELES, GILSON P.; LIRA, FABIO SANTOS; ROMAO, PEDRO R. T.; KRUEGER, KARSTEN; ROSA-NETO, JOSE CESAR; PERES, ALESSANDRA; ANTUNES, BARBARA MOURA. Levels of cardiorespiratory fitness in men exerts strong impact on lymphocyte function after mitogen stimulation. Journal of Applied Physiology, v. 130, n. 4, p. 1133-1142, . (14/08003-1)
ANTUNES, BARBARA MOURA; ROSA-NETO, JOSE CESAR; PEREIRA BATATINHA, HELENA ANGELICA; FRANCHINI, EMERSON; TEIXEIRA, ANA MARIA; LIRA, FABIO SANTOS. Physical fitness status modulates the inflammatory proteins in peripheral blood and circulating monocytes: role of PPAR-gamma. SCIENTIFIC REPORTS, v. 10, n. 1, . (14/08003-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANTUNES, Barbara de Moura Mello. Envolvimento do NF-kB e PPAR-gama na resposta inflamatória e metabólica em monócitos de pessoas com diferentes níveis de condicionamento físico na resposta ao exercício agudo de diferentes intensidades. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.

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