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The role of the Macrophage Migration Inhibitory Factor in the modulation of the tumor inflammatory infiltrate and progression of oral squamous cell carcinoma

Grant number: 15/02584-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2015
Effective date (End): October 31, 2019
Field of knowledge:Health Sciences - Medicine
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Marcos Brasilino de Carvalho
Home Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated scholarship(s):15/15170-4 - Study of the role of the Macrophage Migration Inhibitory Factor in the modulation of the tumor inflammatory infiltrate and progression of oral squamous cell carcinoma, BE.EP.DR


INTRODUCTION. Inflammation participates in the different stages of carcinogenesis and tumor progression in the most of the neoplasms. The cancer-associated inflammation, including tumor-associated macrophages, plays different mechanisms depending on the type and frequency of received stimuli, and according of this can display pro or anti-tumor functions. MIF protein acts in the modulation of the tumor imune response, and a range of investigations have shown that it can induce the polarization of macrophages located in the tumor stroma to an immunosupressive and protumoral M2 phenotype. OBJECTIVES. The present study aims assess in vitro the role of MIF protein on the modulation of tumor-associated macrophages and the impact of it on oral squamous cell carcinoma behavior. METHODS. Macrophages from tumor tissue, as well as from healthy subject´s periferic blood will be obtained and treated in vitro with conditioned media from MIF knockout and wild type SCC15 and SCC25 oral squamous cell carcinoma cell lines. Then the macrophages will be evaluated based on the M1 and M2 phenotype. Functional experiments will be performed to verify the role of the different tumor-associated macrophage´s phenotypes in SCC´s migration, invasion and proliferation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA RIZZO, M. BARBOSA; BRASILINO DE CARVALHO, M.; KIM, E. J.; RENDON, B. E.; NOE, J. T.; WISE, A. DARLENE; MITCHELL, R. A.. Oral squamous carcinoma cells promote macrophage polarization in an MIF-dependent manner. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE, v. 111, n. 11, p. 769-778, . (15/15170-4, 15/02584-5, 15/03453-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
RIZZO, MARIANA BARBOSA DE SOUZA. Role of the macrophage migration inhibitory factor (MIF) in the modulation of the tumor associated macrophages in oral squamous cell carcinoma. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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