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Study of an small heat shock protein expression in the Malaria rodent model

Grant number: 15/04005-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2015
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Parasitology - Protozoology of Parasites
Principal researcher:Georgina Nuri Montagna
Grantee:Gesislania de Sousa
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:13/14361-5 - Plasmodium parasite motility: identification of new candidates for drug targeting and validation of vaccine candidates, AP.JP

Abstract

We had previously identified a heat shock protein involved in the migration and natural transmission of the malaria parasite. To further characterize the regulation of the molecular motor, we search for additional members of this family protein. A new small chaperone protein was identified, which is expressed at different parasite stages. Interestingly, this molecule of 17 kDa (Hsp17) is possibly found in Plasmodium erythrocityc stages and involved during parasite development. We propose to analyze the expression and localization of Hsp17 protein during Plasmodium berghei life cycle.

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