Trinuclear ruthenium carboxylates with functional ligands CO, NO and intercalators: chemical study and interactions with biomolecules target

Abstract

This project aims to contribute significantly to the study of trinuclear ruthenium carboxylate focusing on bioinorganic area. Thus, it is planned to develop a new series of complexes with ligands intercalators of the type [Ru3O(OAc)5(py)2(L)](PF6), where py = pyridine, and L = 1,10-phenanthroline (1) , dppz (2) CH3 dppz (3) Cl-dppz (4), NO2 dppz (5). The complexes are synthesized according to the synthetic routes described in the literature and adaptations will be characterized using the techniques of UV-visible spectroscopy, IR, 1H and 13C NMR, elemental analysis, mass spectroscopy and cyclic voltammetry. The interaction between the new complexes with biomolecules such as calf thymus DNA and human serum albumin (HSA) by means of spectroscopic UV-visible and/or luminescence will be investigated. In addition to the synthesis and characterization of new complexes will be held kinetic and photochemical studies to investigate the CO and NO release mechanisms of the complex [Ru3O (OAc)6(4-acpy)2(CO)](1a), [Ru3O(OAc)6(4-tbpy) 2(CO)](2a), [Ru3O(OAc)6(4-acpy)2(NO)PF6(3a), [Ru3O(OAc)6(4-tbpy)2(NO)]PF6(4a). (AU)