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Effects of exposure to ivermectin in rats: reproductive aspects in male and female

Grant number: 15/03131-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2015
Effective date (End): July 31, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Helenice de Souza Spinosa
Grantee:Natalia Moreira
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Ivermectin is a macrocyclic lactone used in the treatment of parasitic infections in humans and widely used in veterinary medicine as endectocide. In mammals, several evidences indicate that interact with the macrocyclic lactones chloride channels mediated by gamma-aminobutyric acid (GABA). It is known that the GABAergic system is involved in the manifestation of sexual behavior. Previous studies from our group about the behavioral effects of acute administration of macrocyclic lactones showed impairment in sexual behavior in rats, and these effects associated with the central GABAergic system. Recently, in our master degree we observed that ivermectin administration in male rats reduced testosterone levels without interfering with sexual motivation and penile erection, while in females impaired sexual behavior. Thus, continuing our studies and to contribute to the understanding of the physiological, pharmacological and molecular mechanisms involved in the effects of ivermectin in the reproductive sphere, in this project we propose to evaluate in male rats testicular function, morphology and motility of semen, and in females, the physiological estrous cycle and in both genders, hormonal status and the expression of sex hormone receptors after 24, 72, 120 and 168 hours of its administration. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORDEIRO, FLORA; GONCALVES, JR., VAGNER; MOREIRA, NATALIA; SLOBODTICOV, JOAO IOSIF; GALVAO, NATHALIA DE ANDRADE; SPINOSA, HELENICE DE SOUZA; BONAMIN, LEONI VILLANO; BONDAN, EDUARDO FERNANDES; PASTOR CISCATO, CLAUDIA HELENA; BARBOSA, CLAUDIA MARIA; et al. Ivermectin acute administration impaired the spermatogenesis and spermiogenesis of adult rats. Research in Veterinary Science, v. 117, p. 178-186, . (15/03131-4)
MOREIRA, N.; VICENTE, F. L.; SANDINI, T. M.; MARTINELLI, E. C. L.; NAVAS-SUAREZ, P. E.; REIS-SILVA, T. M.; SPINOSA, H. S.. Effects of ivermectin treatment during prepubertal and pubertal period on sexual parameters and sexual behavior in adulthood in rats. Research in Veterinary Science, v. 129, p. 21-27, . (17/00020-2, 15/03131-4)
MOREIRA, N.; TORRES, M. A.; NAVAS-SUAREZ, P. E.; GONCALVES, JR., V.; RASPANTINI, P. C. F.; RASPANTINI, L. E. R.; GOTARDO, A. T.; ANDRADE, A. F. C.; SPINOSA, H. S.. Ivermectin does not interfere with seminal and hormonal parameters in male rabbits. Theriogenology, v. 124, p. 32-38, . (15/03131-4)
MOREIRA, N.; SANDINI, T. M.; REIS-SILVA, T. M.; NAVAS-SUARESZ, P.; AUADA, A. V. V.; LEBRUN, I.; FLORIO, J. C.; BERNARDI, M. M.; SPINOSA, H. S.. Ivermectin reduces motor coordination, serum testosterone, and central neurotransmitter levels but does not affect sexual motivation in male rats. REPRODUCTIVE TOXICOLOGY, v. 74, p. 195-203, . (15/03131-4)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MOREIRA, Natalia. Effects of ivermectin exposure in rats and rabbits: reproductive parameters. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.

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