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Flavonoids effect on endodontic microorganisms and its influence in the mineralization markers expression

Grant number: 15/00812-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2015
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Dentistry - Endodontics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Cristiane Duque
Grantee:Loiane Massunari
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


In young permanent teeth that suffered irreversible damage due the infection or local trauma before of the normal physiological closure of the root apex, beyond to treat the infection, there is also the need of the apex lock and apical periodontitis remineralization, representing a real clinical challenge. Even after endodontic treatment, both in teeth with open apex or not, refractory infections may develop because of persistent or invasion of new pathogens. Synthetic materials more suitable for the treatment of primary and permanent teeth with pulp / periapical involvement are calcium hydroxide (CH) and mineral trioxide aggregate (MTA). However, currently has studied biological materials that can stimulate the natural tissue regeneration preserving the epithelial sheath of Hertwig in order to stimulate the differentiation of cells of the apical papilla in odontoblasts. Many authors have explored the use of herbal medicines in order to obtain new compounds that have therapeutic properties. Among these, are flavonoids, natural phenolic compounds which are present in fruits and vegetables and have different properties, such as antimicrobial, antioxidant, osteogenic and antiosteoclastogênica. Thus the aim of this study is to analyze the antimicrobial activity of flavonoids Taxifolin, Pinocembrin, Galangin and Chrysin against Enterococcus faecalis, Pseudomonas aeruginosa, Candida albicans and Actinomyces israelii in planktonic culture and biofilm; and to determine the effect of these flavonoids on the genes expression related to the bone and dentin mineralization process. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MASSUNARI, LOIANE; RABELO, RAFAELA LARUZO; LEITE, MARIA LUISA; SOARES, DIANA GABRIELA; ANOVAZZI, GIOVANA; SOUZA COSTA, CARLOS ALBERTO; DUQUE, CRISTIANE. Dose- and time-dependent effects of taxifolin on viability and mineralization markers of osteoblast-like cells. Brazilian Oral Research, v. 35, . (15/00812-0, 17/10940-1, 19/02129-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MASSUNARI, Loiane. Efeito de flavonoides sobre microrganismos de interesse endodôntico e sua influência na expressão de marcadores de mineralização. 2018. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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