In the last years, the indiscriminate use of medicines and the constant act of self-medication increased the concern about the existence of multi-resistant bacteria to the antibiotics. So, the studies on synthesis of new metallopharmaceutical agents that may have more efficacy than those used in the clinics are of great interest. In this context, the sulfa drugs become even more interesting, especially due to its bacteriostatic activities and the number of new compounds that can be created from them, such as the metallic complexes. In this subject, two elements deserve attention by their antimicrobial activities: copper and silver. This project aims to synthesize and characterize new complexes of silver(I) and copper(II) with acetazolamide and the study of the antibacterial activity of such compounds over Gram-positive and Gram-negative bacterial strains.
News published in Agência FAPESP Newsletter about the scholarship: