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Longitudinal clinical and microbiological evaluation of one-stage full-mouth disinfection in obese subjects

Grant number: 15/02995-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2015
Effective date (End): May 31, 2017
Field of knowledge:Health Sciences - Dentistry - Periodontology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:José Roberto Cortelli
Grantee:Taís Browne de Miranda
Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade de Taubaté (UNITAU). Taubaté , SP, Brazil


Hypothesis: the full-mouth disinfection protocol will lead to clinical and microbial improvements in both groups; however, the magnitude of effects could be better in obese individuals. Aim: the aim of this parallel controlled clinical trial will be evaluate the magnitude of full-mouth disinfection protocol effects on obese individuals against normal-weight/overweight. Both groups diagnosed with moderate to advanced chronic periodontitis. Methods: the study population will consist of 60 subjects (30 obese) and (30 normal-weight/overweight), both gender, at least 18 years of age, no use of systemic antibiotics or nonsteroidal anti-inflammatory drugs 3 months before the study. Will be excluded individuals participants in weight control program, with history of periodontal treatment six months before the study and pregnant and lactant women. Longitudinal clinical examinations including periodontal pocket depth, clinical attachment level, plaque index and gingival index will be performed during the trial as to compare the obese responses. Quantitative (qPCR) evaluations of the oral microorganisms P. gingivalis, T. forsythia and T. denticola will be also done. All clinical and microbial exams will be performed at baseline, 3 and 6 months. Analyze of results: descriptive data will be analyzed through measures of central tendency, confidence interval and standard deviation. Treatment outcomes will be analyzed using parametric and nonparametric statistics (p < 0.05). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CORTELLI, SHEILA C.; COSTA, FERNANDO O.; GARGIONI-FILHO, ANTONIO; AQUINO, DAVI R.; COTA, LUIS O. M.; SCHERMA, ALEXANDRE P.; MIRANDA, THIS B.; CORTELLI, JOSE R.. Impact of gingivitis treatment for diabetic patients on quality of life related to periodontal objective parameters: A randomized controlled clinical trial. ARCHIVES OF ORAL BIOLOGY, v. 86, p. 80-86, . (15/02995-5, 10/20424-1)
ALCIONE M. S. D. OLIVEIRA; FERNANDO O. COSTA; LETÍCIA MARA R. NOGUEIRA; SHEILA C. CORTELLI; PETERSON A. D OLIVEIRA; DAVI R. AQUINO; TAÍS B. MIRANDA; JOSÉ R. CORTELLI. Azithromycin and Full-Mouth Scaling For the Treatment of Generalized Stage III and IV Periodontitis: A 6-Month Randomized Comparative Clinical Trial. Brazilian Dental Journal, v. 30, n. 5, p. 429-436, . (15/02890-9, 15/02995-5)
PERALTA, FELIPE DA SILVA; CORTELLI, SHEILA CAVALCA; ROVAL, EMANUEL SILVA; AQUINO, DAVI ROMEIRO; MIRANDA, TAIS BROWNE; COSTA, FERNANDO OLIVEIRA; CORTELLI, JOSE ROBERTO. Clinical and microbiological evaluation of non-surgical periodontal therapy in obese and non-obese individuals with periodontitis: a 9-month prospective longitudinal study. Journal of Applied Oral Science, v. 28, . (15/02995-5)

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