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Semantic processing of the audiovisual information in autism: an electrophysiological exploration

Grant number: 15/00553-5
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2015
Effective date (End): May 31, 2018
Field of knowledge:Humanities - Psychology - Physiological Psychology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Paulo Sérgio Boggio
Grantee:Mirella Manfredi
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Presbiteriana Mackenzie (UPM). Instituto Presbiteriano Mackenzie. São Paulo , SP, Brazil


The aim of this project consists in deeply analyzing several aspects related to semantic processing in autism. In particular, we are going to focus on the semantic processing of the audiovisual stimuli. Since previous works reported mixed findings, we are going to perform an electrophysiological project that could shed some light on these questions. In particular, we are going to carry out three different experiments to clarify several aspects of the phenomenon. In the first study we are investigating if, in ASD children, the semantic processing presented in a unisensory modality is impaired both during the presentation of verbal and nonverbal stimuli. In a second study, we are going to investigate if the semantic processing is compromised when a verbal or nonverbal stimulus has to be integrated in a previous context. Finally, in the third study we are going to investigate the semantic processing in ASD children when stimuli are presented simultaneously. Specifically we are going to compare the electrophysiological responses in a group of ASD scholar-aged children to a control group matched on IQ, and a control group matched on chronological age. We are going to record the event-related potentials to evaluate whether the N400 and late positive potential (LPP) components, two widely studied electrophysiological markers of semantic processing, are differently modulated in ASD children and controls. Therefore, aim of this project is to clarify if the deficit showed by this clinical population is specific to a particular sensory modality (verbal), or concerns to a more generalized impairment in the semantic area. In addition, it could clarify the nature of the audiovisual integration deficit in ASD children.This aspect is particularly critical because the ability to integrate simultaneous stimuli from different sensory modalities may affect the everyday life interactions. We believe that the results of this project may have important implications for diagnosis and treatments of ASD children at an early stage. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MANFREDI, MIRELLA; PROVERBIO, ALICE MADO; DE PINHO, PAMELLA SANCHEZ MELLO; RIBEIRO, BEATRIZ; COMFORT, WILLIAM EDGAR; MURRINS MARQUES, LUCAS; BOGGIO, PAULO SERGIO. Electrophysiological indexes of ToM and non-ToM humor in healthy adults. Experimental Brain Research, v. 238, n. 4, . (15/00553-5, 17/12752-8, 17/06136-2)
MANFREDI, MIRELLA; COHN, NEIL; ANDREOLI, MARIANA DE ARAUJO; BOGGIO, PAULO SERGIO. Listening beyond seeing: Event-related potentials to audiovisual processing in visual narrative. BRAIN AND LANGUAGE, v. 185, p. 1-8, . (15/00553-5)
MANFREDI, MIRELLA; COHN, NEIL; RIBEIRO, BEATRIZ; PINHO, PAMELLA SANCHEZ; RODRIGUES PEREIRA, ELISABETE FERNANDES; BOGGIO, PAULO SERGIO. The electrophysiology of audiovisual processing in visual narratives in adolescents with autism spectrum disorder. BRAIN AND COGNITION, v. 151, . (15/00553-5)
MANFREDI, MIRELLA; PROVERBIO, ALICE MADO; MARQUES, LUCAS MURRINS; RIBEIRO, BEATRIZ; NAKAO MORELLO, LETICIA YUMI; BOGGIO, PAULO SERGIO. Anodal transcranial direct current stimulation of MPFC enhances humor processing. Social Neuroscience, . (16/19282-4, 15/00553-5, 16/19277-0)
MANFREDI, MIRELLA; COHN, NEIL; SANCHEZ MELLO, PAMELLA; FERNANDEZ, ELIZABETH; BOGGIO, PAULO SERGIO. Visual and Verbal Narrative Comprehension in Children and Adolescents with Autism Spectrum Disorders: An ERP Study. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, v. 50, n. 8, p. 2658-2672, . (15/00553-5)
MANFREDI, MIRELLA; PROVERBIO, ALICE MADO; GONCALVES DONATE, ANA PAULA; GONCALVES VIEIRA, SOFIA MACARINI; COMFORT, WILLIAM EDGAR; ANDREOLI, MARIANA DE ARAUJO; BOGGIO, PAULO SERGIO. tDCS application over the STG improves the ability to recognize and appreciate elements involved in humor processing. Experimental Brain Research, v. 235, n. 6, p. 1843-1852, . (15/00553-5)
MANFREDI, MIRELLA; MELLO DE PINHO, PAMELLA SANCHEZ; MARQUES, LUCAS MURRINS; RIBEIRO, BEATRIZ DE OLIVEIRA; BOGGIO, PAULO SERGIO. Crossmodal processing of environmental sounds and everyday life actions: An ERP study. HELIYON, v. 7, n. 9, . (17/06136-2, 16/19277-0, 15/00553-5)

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